@article{oai:niigata-u.repo.nii.ac.jp:00006448,
 author = {Fujiwara, Hiroshi and Tazawa, Toshio and Yamamoto, Ayako and Ito, Masaaki},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {Arsenical keratosis (AK) is a common early sign of chronic arsenicism. The association between arsenicism and Bowen's disease is well documented, but a definitive understanding of the relation between AK and Bowen's disease remains elusive. In this study, eight cases of AK were examined immunohistologically with antibodies for cytokeratins, epidermal growth factor receptor, erbB2 protein, c-myc protein, and ki-67. An in situ hybridization study for c-myc, v-erb-B, and erbB2 mRNA was also performed. Bowen's disease (16 cases) and normal skin (3 cases) of arsenic ingesters, and Bowen's disease (15 cases) and seborrheic keratosis (15 cases) without arsenic exposure served as controls. AK revealed a similar reaction to Bowen's disease, with characteristic positive cells for ki-67 antigen and c-myc mRNA in the suprabasal layers. These findings demonstrate a close relationship between AK and Bowen's disease.},
 pages = {37--42},
 title = {An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis},
 volume = {44},
 year = {1996}
}