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An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis
http://hdl.handle.net/10191/33156
http://hdl.handle.net/10191/331564f9777a2-6001-453a-a2c2-24b2ae7a683d
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-27 | |||||
タイトル | ||||||
タイトル | An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | arsenic | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | arsenical keratosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bowen's disease | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Fujiwara, Hiroshi
× Fujiwara, Hiroshi× Tazawa, Toshio× Yamamoto, Ayako× Ito, Masaaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Arsenical keratosis (AK) is a common early sign of chronic arsenicism. The association between arsenicism and Bowen's disease is well documented, but a definitive understanding of the relation between AK and Bowen's disease remains elusive. In this study, eight cases of AK were examined immunohistologically with antibodies for cytokeratins, epidermal growth factor receptor, erbB2 protein, c-myc protein, and ki-67. An in situ hybridization study for c-myc, v-erb-B, and erbB2 mRNA was also performed. Bowen's disease (16 cases) and normal skin (3 cases) of arsenic ingesters, and Bowen's disease (15 cases) and seborrheic keratosis (15 cases) without arsenic exposure served as controls. AK revealed a similar reaction to Bowen's disease, with characteristic positive cells for ki-67 antigen and c-myc mRNA in the suprabasal layers. These findings demonstrate a close relationship between AK and Bowen's disease. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 1, p. 37-42, 発行日 1996-03 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |