{"_buckets": {"deposit": "89fde38a-7911-4e8a-971b-035a5d3e35b7"}, "_deposit": {"id": "6448", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6448"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006448"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "42", "bibliographicPageStart": "37", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Arsenical keratosis (AK) is a common early sign of chronic arsenicism. The association between arsenicism and Bowen\u0027s disease is well documented, but a definitive understanding of the relation between AK and Bowen\u0027s disease remains elusive. In this study, eight cases of AK were examined immunohistologically with antibodies for cytokeratins, epidermal growth factor receptor, erbB2 protein, c-myc protein, and ki-67. An in situ hybridization study for c-myc, v-erb-B, and erbB2 mRNA was also performed. Bowen\u0027s disease (16 cases) and normal skin (3 cases) of arsenic ingesters, and Bowen\u0027s disease (15 cases) and seborrheic keratosis (15 cases) without arsenic exposure served as controls. AK revealed a similar reaction to Bowen\u0027s disease, with characteristic positive cells for ki-67 antigen and c-myc mRNA in the suprabasal layers. These findings demonstrate a close relationship between AK and Bowen\u0027s disease.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujiwara, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "52974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tazawa, Toshio"}], "nameIdentifiers": [{"nameIdentifier": "52975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Ayako"}], "nameIdentifiers": [{"nameIdentifier": "52976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Masaaki"}], "nameIdentifiers": [{"nameIdentifier": "52977", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "44(1)_37-42.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "44(1)_37-42.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6448/files/44(1)_37-42.pdf"}, "version_id": "5aa46b1e-2dde-49b8-ae0f-a0a9b0eb3fdf"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "arsenic", "subitem_subject_scheme": "Other"}, {"subitem_subject": "arsenical keratosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bowen\u0027s disease", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis"}, {"subitem_title": "An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/620"], "permalink_uri": "http://hdl.handle.net/10191/33156", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-27"}, "publish_date": "2015-08-27", "publish_status": "0", "recid": "6448", "relation": {}, "relation_version_is_last": true, "title": ["An Immunohistological and in Situ Hybridization Study of Arsenical Keratosis"], "weko_shared_id": null}