{"created":"2021-03-01T06:10:19.425928+00:00","id":6418,"links":{},"metadata":{"_buckets":{"deposit":"ddb6c5c6-5d68-44f8-a202-d8d5e6184784"},"_deposit":{"id":"6418","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6418"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006418","sets":["453:456","471:537:568:617"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"191","bibliographicPageStart":"187","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Serum IL-6 concentration is a sensitive, early marker of tissue damage. However, the importance of locally acting cytokines often outweighs that of systemic cytokines measured in the serum. Study design: We investigated the relationship between the type of surgical procedure and the response of regional TNF-a and IL-6 concentrations. We measured changes in cytokine concentrations in the wound fluid of 14 patients following transthoracic esophagectomy for carcinoma of the esophagus and compared them with those of 6 patients who underwent breast surgery. Results: A significant difference in the time course of changes in the TNF-a concentrations was found between the esophagectomy and breast surgery groups. Regional IL-6 concentrations were significantly higher in the esophagectomy group than in the breast surgery group during the first 72 h postoperatively. Conclusion: Our results suggest that the magnitude of tissue injury influences regional TNF-a and IL-6 concentrations as well as systemic serum IL-6 concentrations, and that the measurement of regional cytokines may lead to a better understanding of the cytokine response mechanism.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Nobuaki"}],"nameIdentifiers":[{"nameIdentifier":"52818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkawa, Akira"}],"nameIdentifiers":[{"nameIdentifier":"52819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oyamatsu, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"52820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koyama, Yu"}],"nameIdentifiers":[{"nameIdentifier":"52821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kayama, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"52822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatakeyama, Katsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"52823","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"44(4)_187-191.pdf","filesize":[{"value":"666.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"44(4)_187-191.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6418/files/44(4)_187-191.pdf"},"version_id":"bc498588-e084-41ce-9092-47fbc1532970"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cytokines","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-6","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-a","subitem_subject_scheme":"Other"},{"subitem_subject":"operation","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue injury","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Does the Magnitude of the Operative Injury Influence Postoperative Regional TNF-a and IL-6 Concentrations?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Does the Magnitude of the Operative Injury Influence Postoperative Regional TNF-a and IL-6 Concentrations?"},{"subitem_title":"Does the Magnitude of the Operative Injury Influence Postoperative Regional TNF-a and IL-6 Concentrations?","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","617"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-27"},"publish_date":"2015-08-27","publish_status":"0","recid":"6418","relation_version_is_last":true,"title":["Does the Magnitude of the Operative Injury Influence Postoperative Regional TNF-a and IL-6 Concentrations?"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:43.730678+00:00"}