@article{oai:niigata-u.repo.nii.ac.jp:00006418,
 author = {Sato, Nobuaki and Ohkawa, Akira and Oyamatsu, Manabu and Koyama, Yu and Kayama, Seiji and Hatakeyama, Katsuyoshi},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {Background: Serum IL-6 concentration is a sensitive, early marker of tissue damage. However, the importance of locally acting cytokines often outweighs that of systemic cytokines measured in the serum. Study design: We investigated the relationship between the type of surgical procedure and the response of regional TNF-a and IL-6 concentrations. We measured changes in cytokine concentrations in the wound fluid of 14 patients following transthoracic esophagectomy for carcinoma of the esophagus and compared them with those of 6 patients who underwent breast surgery. Results: A significant difference in the time course of changes in the TNF-a concentrations was found between the esophagectomy and breast surgery groups. Regional IL-6 concentrations were significantly higher in the esophagectomy group than in the breast surgery group during the first 72 h postoperatively. Conclusion: Our results suggest that the magnitude of tissue injury influences regional TNF-a and IL-6 concentrations as well as systemic serum IL-6 concentrations, and that the measurement of regional cytokines may lead to a better understanding of the cytokine response mechanism.},
 pages = {187--191},
 title = {Does the Magnitude of the Operative Injury Influence Postoperative Regional TNF-a and IL-6 Concentrations?},
 volume = {44},
 year = {1996}
}