@article{oai:niigata-u.repo.nii.ac.jp:00006417,
 author = {Yamamura, Soichiro and Miyaji, Chikako and Watanabe, Hisami and Kawamura, Toshihiko and Fukuda, Minoru and Abo, Toru},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {Some traditional Chinese medicines are known to have paradoxical effects. For example, one such medicine (i.e., glycyrrhizin) is effective for the treatment of allergic diseases (i.e., lymphocyte-associated inflammation), and is also sometimes effective for the treatment of suppurative diseases (i.e., granulocyte-associated inflammation). To investigate the mechanisms underlying this paradox, we conducted a study in mice. When normal mice were administered with one i. p. injection of glycyrrhizin, granulocytes and extrathymic T cells increased in proportion and number in various immune organs. However, an opposite response of glycyrrhizin was induced with such an injection in mice with preexisting granulocytosis. These mice included those treated with G-CSF and AIDS mice infected with murine leukemia virus. In other words, glycyrrhizin reduced the levels of granulocytes and extrathymic T cells in various organs of mice with preexisting granulocytosis. These results suggest that some drugs have the ability to exert paradoxical effects, depending on the conditions of the host immune system. The underlying mechanisms are discussed.},
 pages = {177--185},
 title = {Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis},
 volume = {44},
 year = {1996}
}