ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "47f8e108-0201-4442-8a44-3b904440ae33"}, "_deposit": {"id": "6417", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6417"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006417", "sets": ["456", "617"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "185", "bibliographicPageStart": "177", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Some traditional Chinese medicines are known to have paradoxical effects. For example, one such medicine (i.e., glycyrrhizin) is effective for the treatment of allergic diseases (i.e., lymphocyte-associated inflammation), and is also sometimes effective for the treatment of suppurative diseases (i.e., granulocyte-associated inflammation). To investigate the mechanisms underlying this paradox, we conducted a study in mice. When normal mice were administered with one i. p. injection of glycyrrhizin, granulocytes and extrathymic T cells increased in proportion and number in various immune organs. However, an opposite response of glycyrrhizin was induced with such an injection in mice with preexisting granulocytosis. These mice included those treated with G-CSF and AIDS mice infected with murine leukemia virus. In other words, glycyrrhizin reduced the levels of granulocytes and extrathymic T cells in various organs of mice with preexisting granulocytosis. These results suggest that some drugs have the ability to exert paradoxical effects, depending on the conditions of the host immune system. The underlying mechanisms are discussed.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "52812", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyaji, Chikako"}], "nameIdentifiers": [{"nameIdentifier": "52813", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Hisami"}], "nameIdentifiers": [{"nameIdentifier": "52814", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Toshihiko"}], "nameIdentifiers": [{"nameIdentifier": "52815", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Minoru"}], "nameIdentifiers": [{"nameIdentifier": "52816", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abo, Toru"}], "nameIdentifiers": [{"nameIdentifier": "52817", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "44(4)_177-185.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "44(4)_177-185.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6417/files/44(4)_177-185.pdf"}, "version_id": "65f9644d-8997-41a8-8882-2f67e293168a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Chinese medicine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glycyrrhizin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lymphocytes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "granulocytes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "extrathymic T cells", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis"}, {"subitem_title": "Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "617"], "permalink_uri": "http://hdl.handle.net/10191/33179", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-27"}, "publish_date": "2015-08-27", "publish_status": "0", "recid": "6417", "relation": {}, "relation_version_is_last": true, "title": ["Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.44 No.4

Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis

http://hdl.handle.net/10191/33179
http://hdl.handle.net/10191/33179
8f846eb2-5bc4-41cf-99ea-87a661a85538
名前 / ファイル ライセンス アクション
44(4)_177-185.pdf 44(4)_177-185.pdf (1.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-27
タイトル
タイトル Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis
タイトル
言語 en
タイトル Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis
言語
言語 eng
キーワード
主題Scheme Other
主題 Chinese medicine
キーワード
主題Scheme Other
主題 glycyrrhizin
キーワード
主題Scheme Other
主題 lymphocytes
キーワード
主題Scheme Other
主題 granulocytes
キーワード
主題Scheme Other
主題 extrathymic T cells
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Yamamura, Soichiro

× Yamamura, Soichiro

WEKO 52812

Yamamura, Soichiro

Search repository
Miyaji, Chikako

× Miyaji, Chikako

WEKO 52813

Miyaji, Chikako

Search repository
Watanabe, Hisami

× Watanabe, Hisami

WEKO 52814

Watanabe, Hisami

Search repository
Kawamura, Toshihiko

× Kawamura, Toshihiko

WEKO 52815

Kawamura, Toshihiko

Search repository
Fukuda, Minoru

× Fukuda, Minoru

WEKO 52816

Fukuda, Minoru

Search repository
Abo, Toru

× Abo, Toru

WEKO 52817

Abo, Toru

Search repository
抄録
内容記述タイプ Abstract
内容記述 Some traditional Chinese medicines are known to have paradoxical effects. For example, one such medicine (i.e., glycyrrhizin) is effective for the treatment of allergic diseases (i.e., lymphocyte-associated inflammation), and is also sometimes effective for the treatment of suppurative diseases (i.e., granulocyte-associated inflammation). To investigate the mechanisms underlying this paradox, we conducted a study in mice. When normal mice were administered with one i. p. injection of glycyrrhizin, granulocytes and extrathymic T cells increased in proportion and number in various immune organs. However, an opposite response of glycyrrhizin was induced with such an injection in mice with preexisting granulocytosis. These mice included those treated with G-CSF and AIDS mice infected with murine leukemia virus. In other words, glycyrrhizin reduced the levels of granulocytes and extrathymic T cells in various organs of mice with preexisting granulocytosis. These results suggest that some drugs have the ability to exert paradoxical effects, depending on the conditions of the host immune system. The underlying mechanisms are discussed.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 44, 号 4, p. 177-185, 発行日 1996-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 19:39:15.396770
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3