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Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis
http://hdl.handle.net/10191/33179
http://hdl.handle.net/10191/331798f846eb2-5bc4-41cf-99ea-87a661a85538
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-27 | |||||
タイトル | ||||||
タイトル | Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Paradoxical Effects of Glycyrrhizin on the Induction of Granulocytes and Extrathymic T Cells between Normal Mice and Mice with Preexisting Granulocytosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chinese medicine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glycyrrhizin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | granulocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | extrathymic T cells | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Yamamura, Soichiro
× Yamamura, Soichiro× Miyaji, Chikako× Watanabe, Hisami× Kawamura, Toshihiko× Fukuda, Minoru× Abo, Toru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Some traditional Chinese medicines are known to have paradoxical effects. For example, one such medicine (i.e., glycyrrhizin) is effective for the treatment of allergic diseases (i.e., lymphocyte-associated inflammation), and is also sometimes effective for the treatment of suppurative diseases (i.e., granulocyte-associated inflammation). To investigate the mechanisms underlying this paradox, we conducted a study in mice. When normal mice were administered with one i. p. injection of glycyrrhizin, granulocytes and extrathymic T cells increased in proportion and number in various immune organs. However, an opposite response of glycyrrhizin was induced with such an injection in mice with preexisting granulocytosis. These mice included those treated with G-CSF and AIDS mice infected with murine leukemia virus. In other words, glycyrrhizin reduced the levels of granulocytes and extrathymic T cells in various organs of mice with preexisting granulocytosis. These results suggest that some drugs have the ability to exert paradoxical effects, depending on the conditions of the host immune system. The underlying mechanisms are discussed. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 4, p. 177-185, 発行日 1996-12 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |