@article{oai:niigata-u.repo.nii.ac.jp:00006415,
 author = {Tazawa, Toshio and Fujiwara, Hiroshi and Ito, Kaoru and Ito, Masaaki and Iwanaga, Toshihiko},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {To investigate the fetal development of the nail epithelium, the expression of hard keratin and epidermal keratin in human fetal skin at various stages of gestation was studied by immunofluorescence microscopy using anti-hair keratin and anti-epidermal keratin 10 monoclonal antibodies. Specimens were obtained from digits and scalps of fetuses at 11, 13, 16 and 20 weeks estimated gestational age. At 11, 13 and 16 weeks, hard keratin was coexpressed with epidermal keratin 10 in the nail epithelial field. At 20 weeks, the epidermal keratin 10 was no longer observed and only hard keratins were expressed in the nail matrix and bed, which were covered by an adult-like mature nail plate. In the hair apparatus and epidermis, such a coexpression of hard keratin and epidermal keratin 10 was not observed in any of the fetal stages examined. In conclusion, the coexpression of hard and epidermal keratins is one biological characteristic of the nail epithelium distinguishable from those of the epidermis and hair apparatus during human fetal development of keratinizing epithelia of the skin.},
 pages = {27--32},
 title = {Coexpression of Hard and Epidermal Keratins in the Nail Unit during Human Fetal Skin Development},
 volume = {45},
 year = {1997}
}