@article{oai:niigata-u.repo.nii.ac.jp:00006411, author = {Cui, Xing and Okamura, Naotaka and Sakaguchi, Takeo and Aono, Takashi and Tsukada, Kazuhiro and Hatakeyama, Katsuyoshi}, issue = {1}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Mar}, note = {The effects of prostaglandin E_1 (PGE) on portal venous blood flow (PVF) and hepatic arterial blood flow (HAF) were examined in hepatectomized rats. The jugular injection of PGE produced a dose-dependent increase in PVF in 90 percent hepatectomized rats. The magnitude of flow responses obtained in order of the PVF per wet liver weight due to PGE fell into the following order: the 66 percent hepatectomized rats, the 90 percent hepatectomized rats, and lastly, the 40 percent hepatectomized rats. Intramuscular injection of indomethacin failed to affect PVF in the 66 percent hepatectomized animals. PGE had no effect on HAF in hepatectomized rats. These results suggest that the PGE action on PVF is amplified according to the volume of liver resected, but such PGE action is diminished when 90 percent of the liver is resected, and endogenous prostaglandins are inactive in the hepatectomized situation.}, pages = {7--10}, title = {Liver Circulatory Response Caused by Prostaglandin E_1 in 90 Percent Hepatectomized Rats}, volume = {45}, year = {1997} }