@article{oai:niigata-u.repo.nii.ac.jp:00006410, author = {Sato, Nobuaki and Ohkawa, Akira and Oyamatsu, Manabu and Koyama, Yu and Kayama, Seiji and Hayashi, Mitsuhiro and Sato, Tomoi and Hatakeyama, Katsuyoshi}, issue = {1}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Mar}, note = {Background: The systemic inflammatory response syndrome (SIRS) occurs after a wide variety of insults. Recent studies have revealed that the number of SIRS criteria exhibited by a patient may have clinical importance. For this reason, we sought to determine whether the magnitude of a surgical insult is associated with the number of SIRS criteria satisfied. Study design: We retrospectively investigated relationships between the number of SIRS criteria and the type of surgical procedure, either transthoracic (n = 79) or transhiatal esophagectomy (n =42), in 121 consecutive male patients younger than 75 years of age with carcinoma of the esophagus. Results: Operative injury was more extensive in the transthoracic group than in the transhiatal group in terms of the mean operative time (392 ± 65 versus 215 ± 70 min, p<0.0001) and estimated intraoperative blood loss (693±309 versus 436±316 mL, p<0.0001). Prevalence of SIRS did not differ between the two groups. Pyrexia was more frequent in the transthoracic group than in the transhiatal group (p =0.004). Conversely, tachypnea was commoner in the transhiatal than in the transthoracic group (p=0.0039). The mean number of SIRS criteria exhibited was the same, 2.1 ±0.9 in the transhiatal group and 2.3±0.7 in the transthoracic group. Conclusion: There was no difference in the mean number of SIRS criteria exhibited following either transthoracic or transhiatal esophagectomy for carcinoma of the esophagus, even though the magnitude of the operative injury was greater in patients undergoing transthoracic esophagectomy in terms of operative time and estimated blood loss. Our results show more a frequent occurrence of fever in the transthoracic group and a higher rate of tachypnea in the transhiatal group, a pattern possibly reflecting mechanical ventilation of the transthoracic patients.}, pages = {1--5}, title = {Influence of Operative Injury on the Systemic Inflammatory Response Syndrome in Esophageal Cancer Surgery}, volume = {45}, year = {1997} }