@article{oai:niigata-u.repo.nii.ac.jp:00006409, author = {Narita, Takuma and Kitazato, Hiroji and Koshimura, Jun and Suzuki, Katsunori and Murata, Masahiko and Ito, Seiki}, issue = {2}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Jun}, note = {To determine whether the administration of an angiotensin-converting enzyme inhibitor (ACEI) affects the renal hemodynamic changes and the renal handling of urinary protein excretion in response to a protein meal ingestion, we examined the changes in creatinine clearance (CCr) and urinary albumin excretion rate (AER) in response to the ingestion of a meal of tuna fish before and after the administration of enalapril 2.5 mg/day for one week in 7 healthy male volunteers. Before treatment with enalapril, CCr 0, 1, 2, and 3 (before and 1, 2, and 3 h after protein loading; mean±SD) were 118.8 ± 21.6, 136.8±21.7, 144.9^* ±23.2 and 135.9 ± 15.3 ml/min/1.73 m^2 (^*: p < 0.05 vs CCr 0), respectively. Corresponding values after treatment with enalapril were 124.9 ±21.4, 146.6^* ± 16.3, 139.3^* ± 16.9 and 136.0^* ±22.7 ml/min/1.73 m^2 (^*: p<0.05 vs CCr 0). Mean CCr 0, CCr 2 and individual maximal CCr after protein loading did not show any significant difference before and after enalapril administration (individual maximal CCr: before enalapril 150.3± 13.7 vs after enalapril 153.4±13.6 ml/min/1.73 m^2 , NS). Irrespective of the administration of enalapril, no significant differences were observed in AER values before and after the ingestion of the tuna fish meal. Thus, it might appear that in humans who have normal renal function and are receiving long-term treatment with ACEI, CCr 2 or individual maximal CCr after the ingestion of a tuna fish meal could be used as an index of "renal functional reserve". Furthermore, irrespective of the administration of enalapril, the ingestion of tuna fish meal did not affect the renal handling of urinary albumin excretion.}, pages = {89--94}, title = {Effects of One Week's Administration of Enalapril on the Renal Hemodynamic Response to the Ingestion of a Protein Meal in Healthy Subjects}, volume = {45}, year = {1997} }