{"created":"2021-03-01T06:10:18.783479+00:00","id":6408,"links":{},"metadata":{"_buckets":{"deposit":"b294e15b-cd96-40de-b927-227e30921d8d"},"_deposit":{"id":"6408","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6408"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006408","sets":["453:456","471:537:568:615"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"87","bibliographicPageStart":"81","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Homogenic T cells were injected into the renal subcapsule of 19 Lewis rats and the liver subcapsule of 8 Lewis rats to examine apoptotic changes induced by T cells. Resulting phenomena were compared with graft-versus-host reaction (GvHR) induced in 5 F_1 (DAxLewis) male rats by the injection of DA female lymphocytes. The positive cell numbers of interleukin II receptor (IL-2R), CD18 or CD5 antigen were counted on the peripheral and splenic lymphocytes. The proportions of peripheral IL-2R (αβ)-positive cells ranged from 3±2% to 12±5% in 23 of the 27 Lewis rats. Splenic IL-2R-positive cells ranged from 10% to 25% in all 27 rats. Based on the numbers of CD5-positive splenic lymphocytes, 20% to 100% of splenic T cells were judged to express IL-2R. In three of the remaining four rats, peripheral IL-2R (αβ)-positive cells ranged from 47% to 85%. One of the four remaining rats showed 94% expression of IL-2R (αβγ) on the peripheral lymphocytes: IL-2R (αβγ)-positive lymphocytes of the rat also expressed strongly CD18 and CD5 antigens. In the F_1 rats with early GvHR, IL-2R expression was observed on 13±2% of peripheral lymphocytes and 59±5% of splenic T lymphocytes, while IL-2R-positive cell % of control F_1 males were 15±7 and 55±9, respectively. Renal tubular disappearance due to apoptosis and glomerular accumulation were found in the renal cortex of the female rat with 94% IL-2R-positive cells. The same renal lesions were also observed in 6 other rats. Abundant Golgi's complexes were shown in a glomerular epithelial cell. In the T cell-inoculated liver, only focal lymphocyte proliferation was found abnormally around the sinusoid without the other apoptotic changes. IL-2R was strongly expressed on hepatocytes surrounding the focal lymphocyte proliferation. In the plasma of the F_1 rats with GvHR, secreted humoral factors which activated monocytes but not neutrophils were indicated by the phagocytic functions of apoptotic cells, in vitro. It was concluded that IL-2R on T cells was activated by homogenic cell reactions such as apoptosis, but not by heterogenic donor cell reactions such as GvHR, in which antiapoptotic interferon (lFN)-like receptors were considered to be activated.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakatsuji, Tadako"}],"nameIdentifiers":[{"nameIdentifier":"52759","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"45(2)_81-87.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"45(2)_81-87.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6408/files/45(2)_81-87.pdf"},"version_id":"889d0a8e-bdb0-436a-aad0-1a2d252afc0e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-2R","subitem_subject_scheme":"Other"},{"subitem_subject":"GvHR","subitem_subject_scheme":"Other"},{"subitem_subject":"Golgi's complex","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)"},{"subitem_title":"Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","615"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-25"},"publish_date":"2015-08-25","publish_status":"0","recid":"6408","relation_version_is_last":true,"title":["Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:41.397490+00:00"}