@article{oai:niigata-u.repo.nii.ac.jp:00006408,
 author = {Nakatsuji, Tadako},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Homogenic T cells were injected into the renal subcapsule of 19 Lewis rats and the liver subcapsule of 8 Lewis rats to examine apoptotic changes induced by T cells. Resulting phenomena were compared with graft-versus-host reaction (GvHR) induced in 5 F_1 (DAxLewis) male rats by the injection of DA female lymphocytes. The positive cell numbers of interleukin II receptor (IL-2R), CD18 or CD5 antigen were counted on the peripheral and splenic lymphocytes. The proportions of peripheral IL-2R (αβ)-positive cells ranged from 3±2% to 12±5% in 23 of the 27 Lewis rats. Splenic IL-2R-positive cells ranged from 10% to 25% in all 27 rats. Based on the numbers of CD5-positive splenic lymphocytes, 20% to 100% of splenic T cells were judged to express IL-2R. In three of the remaining four rats, peripheral IL-2R (αβ)-positive cells ranged from 47% to 85%. One of the four remaining rats showed 94% expression of IL-2R (αβγ) on the peripheral lymphocytes: IL-2R (αβγ)-positive lymphocytes of the rat also expressed strongly CD18 and CD5 antigens. In the F_1 rats with early GvHR, IL-2R expression was observed on 13±2% of peripheral lymphocytes and 59±5% of splenic T lymphocytes, while IL-2R-positive cell % of control F_1 males were 15±7 and 55±9, respectively. Renal tubular disappearance due to apoptosis and glomerular accumulation were found in the renal cortex of the female rat with 94% IL-2R-positive cells. The same renal lesions were also observed in 6 other rats. Abundant Golgi's complexes were shown in a glomerular epithelial cell. In the T cell-inoculated liver, only focal lymphocyte proliferation was found abnormally around the sinusoid without the other apoptotic changes. IL-2R was strongly expressed on hepatocytes surrounding the focal lymphocyte proliferation. In the plasma of the F_1 rats with GvHR, secreted humoral factors which activated monocytes but not neutrophils were indicated by the phagocytic functions of apoptotic cells, in vitro. It was concluded that IL-2R on T cells was activated by homogenic cell reactions such as apoptosis, but not by heterogenic donor cell reactions such as GvHR, in which antiapoptotic interferon (lFN)-like receptors were considered to be activated.},
 pages = {81--87},
 title = {Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)},
 volume = {45},
 year = {1997}
}