{"_buckets": {"deposit": "b294e15b-cd96-40de-b927-227e30921d8d"}, "_deposit": {"id": "6408", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6408"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006408"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "87", "bibliographicPageStart": "81", "bibliographicVolumeNumber": "45", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Homogenic T cells were injected into the renal subcapsule of 19 Lewis rats and the liver subcapsule of 8 Lewis rats to examine apoptotic changes induced by T cells. Resulting phenomena were compared with graft-versus-host reaction (GvHR) induced in 5 F_1 (DAxLewis) male rats by the injection of DA female lymphocytes. The positive cell numbers of interleukin II receptor (IL-2R), CD18 or CD5 antigen were counted on the peripheral and splenic lymphocytes. The proportions of peripheral IL-2R (\u03b1\u03b2)-positive cells ranged from 3\u00b12% to 12\u00b15% in 23 of the 27 Lewis rats. Splenic IL-2R-positive cells ranged from 10% to 25% in all 27 rats. Based on the numbers of CD5-positive splenic lymphocytes, 20% to 100% of splenic T cells were judged to express IL-2R. In three of the remaining four rats, peripheral IL-2R (\u03b1\u03b2)-positive cells ranged from 47% to 85%. One of the four remaining rats showed 94% expression of IL-2R (\u03b1\u03b2\u03b3) on the peripheral lymphocytes: IL-2R (\u03b1\u03b2\u03b3)-positive lymphocytes of the rat also expressed strongly CD18 and CD5 antigens. In the F_1 rats with early GvHR, IL-2R expression was observed on 13\u00b12% of peripheral lymphocytes and 59\u00b15% of splenic T lymphocytes, while IL-2R-positive cell % of control F_1 males were 15\u00b17 and 55\u00b19, respectively. Renal tubular disappearance due to apoptosis and glomerular accumulation were found in the renal cortex of the female rat with 94% IL-2R-positive cells. The same renal lesions were also observed in 6 other rats. Abundant Golgi\u0027s complexes were shown in a glomerular epithelial cell. In the T cell-inoculated liver, only focal lymphocyte proliferation was found abnormally around the sinusoid without the other apoptotic changes. IL-2R was strongly expressed on hepatocytes surrounding the focal lymphocyte proliferation. In the plasma of the F_1 rats with GvHR, secreted humoral factors which activated monocytes but not neutrophils were indicated by the phagocytic functions of apoptotic cells, in vitro. It was concluded that IL-2R on T cells was activated by homogenic cell reactions such as apoptosis, but not by heterogenic donor cell reactions such as GvHR, in which antiapoptotic interferon (lFN)-like receptors were considered to be activated.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakatsuji, Tadako"}], "nameIdentifiers": [{"nameIdentifier": "52759", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "45(2)_81-87.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "45(2)_81-87.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6408/files/45(2)_81-87.pdf"}, "version_id": "889d0a8e-bdb0-436a-aad0-1a2d252afc0e"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "apoptosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-2R", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GvHR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Golgi\u0027s complex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rat", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)"}, {"subitem_title": "Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/615"], "permalink_uri": "http://hdl.handle.net/10191/33124", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-25"}, "publish_date": "2015-08-25", "publish_status": "0", "recid": "6408", "relation": {}, "relation_version_is_last": true, "title": ["Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)"], "weko_shared_id": null}