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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.45 No.2

Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)

http://hdl.handle.net/10191/33124
http://hdl.handle.net/10191/33124
bb362794-de81-4a89-8bd4-5b8e55085ab8
名前 / ファイル ライセンス アクション
45(2)_81-87.pdf 45(2)_81-87.pdf (1.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-25
タイトル
タイトル Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)
タイトル
言語 en
タイトル Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)
言語
言語 eng
キーワード
主題Scheme Other
主題 apoptosis
キーワード
主題Scheme Other
主題 IL-2R
キーワード
主題Scheme Other
主題 GvHR
キーワード
主題Scheme Other
主題 Golgi's complex
キーワード
主題Scheme Other
主題 rat
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Nakatsuji, Tadako

× Nakatsuji, Tadako

WEKO 52759

Nakatsuji, Tadako

Search repository
抄録
内容記述タイプ Abstract
内容記述 Homogenic T cells were injected into the renal subcapsule of 19 Lewis rats and the liver subcapsule of 8 Lewis rats to examine apoptotic changes induced by T cells. Resulting phenomena were compared with graft-versus-host reaction (GvHR) induced in 5 F_1 (DAxLewis) male rats by the injection of DA female lymphocytes. The positive cell numbers of interleukin II receptor (IL-2R), CD18 or CD5 antigen were counted on the peripheral and splenic lymphocytes. The proportions of peripheral IL-2R (αβ)-positive cells ranged from 3±2% to 12±5% in 23 of the 27 Lewis rats. Splenic IL-2R-positive cells ranged from 10% to 25% in all 27 rats. Based on the numbers of CD5-positive splenic lymphocytes, 20% to 100% of splenic T cells were judged to express IL-2R. In three of the remaining four rats, peripheral IL-2R (αβ)-positive cells ranged from 47% to 85%. One of the four remaining rats showed 94% expression of IL-2R (αβγ) on the peripheral lymphocytes: IL-2R (αβγ)-positive lymphocytes of the rat also expressed strongly CD18 and CD5 antigens. In the F_1 rats with early GvHR, IL-2R expression was observed on 13±2% of peripheral lymphocytes and 59±5% of splenic T lymphocytes, while IL-2R-positive cell % of control F_1 males were 15±7 and 55±9, respectively. Renal tubular disappearance due to apoptosis and glomerular accumulation were found in the renal cortex of the female rat with 94% IL-2R-positive cells. The same renal lesions were also observed in 6 other rats. Abundant Golgi's complexes were shown in a glomerular epithelial cell. In the T cell-inoculated liver, only focal lymphocyte proliferation was found abnormally around the sinusoid without the other apoptotic changes. IL-2R was strongly expressed on hepatocytes surrounding the focal lymphocyte proliferation. In the plasma of the F_1 rats with GvHR, secreted humoral factors which activated monocytes but not neutrophils were indicated by the phagocytic functions of apoptotic cells, in vitro. It was concluded that IL-2R on T cells was activated by homogenic cell reactions such as apoptosis, but not by heterogenic donor cell reactions such as GvHR, in which antiapoptotic interferon (lFN)-like receptors were considered to be activated.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 45, 号 2, p. 81-87, 発行日 1997-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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