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Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR)
http://hdl.handle.net/10191/33124
http://hdl.handle.net/10191/33124bb362794-de81-4a89-8bd4-5b8e55085ab8
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-25 | |||||
タイトル | ||||||
タイトル | Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Renal or Liver Apoptotic Changes Triggered by Inoculation of Homogenic T Cells and Ensuring High IL-2R Expression on T Cells : A Comparison with Early Graft-versus-Host Reaction (GvHR) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-2R | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GvHR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Golgi's complex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Nakatsuji, Tadako
× Nakatsuji, Tadako |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Homogenic T cells were injected into the renal subcapsule of 19 Lewis rats and the liver subcapsule of 8 Lewis rats to examine apoptotic changes induced by T cells. Resulting phenomena were compared with graft-versus-host reaction (GvHR) induced in 5 F_1 (DAxLewis) male rats by the injection of DA female lymphocytes. The positive cell numbers of interleukin II receptor (IL-2R), CD18 or CD5 antigen were counted on the peripheral and splenic lymphocytes. The proportions of peripheral IL-2R (αβ)-positive cells ranged from 3±2% to 12±5% in 23 of the 27 Lewis rats. Splenic IL-2R-positive cells ranged from 10% to 25% in all 27 rats. Based on the numbers of CD5-positive splenic lymphocytes, 20% to 100% of splenic T cells were judged to express IL-2R. In three of the remaining four rats, peripheral IL-2R (αβ)-positive cells ranged from 47% to 85%. One of the four remaining rats showed 94% expression of IL-2R (αβγ) on the peripheral lymphocytes: IL-2R (αβγ)-positive lymphocytes of the rat also expressed strongly CD18 and CD5 antigens. In the F_1 rats with early GvHR, IL-2R expression was observed on 13±2% of peripheral lymphocytes and 59±5% of splenic T lymphocytes, while IL-2R-positive cell % of control F_1 males were 15±7 and 55±9, respectively. Renal tubular disappearance due to apoptosis and glomerular accumulation were found in the renal cortex of the female rat with 94% IL-2R-positive cells. The same renal lesions were also observed in 6 other rats. Abundant Golgi's complexes were shown in a glomerular epithelial cell. In the T cell-inoculated liver, only focal lymphocyte proliferation was found abnormally around the sinusoid without the other apoptotic changes. IL-2R was strongly expressed on hepatocytes surrounding the focal lymphocyte proliferation. In the plasma of the F_1 rats with GvHR, secreted humoral factors which activated monocytes but not neutrophils were indicated by the phagocytic functions of apoptotic cells, in vitro. It was concluded that IL-2R on T cells was activated by homogenic cell reactions such as apoptosis, but not by heterogenic donor cell reactions such as GvHR, in which antiapoptotic interferon (lFN)-like receptors were considered to be activated. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 45, 号 2, p. 81-87, 発行日 1997-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |