@article{oai:niigata-u.repo.nii.ac.jp:00006400, author = {Suzuki, Satoshi and Saitoh, Hiroshi and Shimizu, Takao and Iinuma, Yasushi and Mishina, Takeshi and Suzuki, Nobuo and Fukase, Masayuki and Sekikawa, Hiroo and Hatakeyama, Katsuyoshi}, issue = {3}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Sep}, note = {An 82-year-old Japanese man with a cecal cancer and a history of Schistosoma japonicum (S. japonicum) infestation underwent ileocecal resection. In the resected specimen many heavily calcified eggs of S. japonicum were seen, distributed mainly in the submucosa adjacent to the tumor. Schistosomiasis due to S. japonicum is one of many possible contributors to the development of colorectal cancer. In this case, the 50 years between the patient's acquisition of S. japonicum and presentation with cancer may reflect unrelated spontaneous carcinogenesis, but the fact that the eggs were heavily and extensively present in the resected specimen argues for a relationship between these eggs and the cancer. Coordinating treatment for schistosomiasis with systemic follow-up to detect cancer probably would be required to establish S. japonicum eggs as a cancer promoter, the infestation of which presumably contributes to the cellular changes leading to premalignant transformation of intestinal epithelial cells.}, pages = {133--137}, title = {Primary Colonic Cancer in Association with Schistosomiasis Japonica : A Case Report}, volume = {45}, year = {1997} }