@article{oai:niigata-u.repo.nii.ac.jp:00006398,
 author = {Motoyama, Hirotaka},
 issue = {3},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Sep},
 note = {This study measured luminol-enhanced chemiluminescence in patients with portal hypertensive gastropathy and investigated whether superficial reddening, a gastric mucosal change observed in patients with portal hypertension, should be included in the category of endoscopic findings of patients with portal hypertensive gastropathy. The subjects consisted of 36 histologically confirmed cirrhotic patients with a snake skin appearance or discrete red spots on the gastric mucosa (Group 1), 42 patients with superficial reddening on the gastric mucosa who had no liver disease (Group 2) and 32 controls. Luminol-enhanced chemiluminescence study of the gastric mucosal biopsy specimens showed that a significantly larger amount of chemiluminescence was produced in Group 1 than in either Group 2 or the controls, and that there was no significant difference between Group 2 and the controls. In histological examination, no significant differences were observed among the three groups in the extent of mucosal infiltration of small round cells and neutrophils. The mean ratio of the total vascular area to total mucosal stromal area was significantly higher in Group 1 and 2 than in the controls. Moreover, the ratio in Group 1 was statistically higher than that in Group 2. In a gastric mucosal hemodynamic study, Group 1 had a higher mean value of the index of mucosal blood volume (IHB ratio) and a lower mean value of the index of mucosal oxygen saturation (ISO_2 ) than Group 2 or the controls, which suggested congestion. In Group 2, ISO_2 was significantly lower than in the control group, but the IHB ratio was not different from the controls, which suggested that the superficial reddening reflected the increased consumption of oxygen in the mucosa but was not associated with congestion. From these findings, it is suggested that the differences in luminolenhanced chemiluminescence are related to the presence and absence of congestion. In view of the fact that congestion plays an important role in portal hypertensive gastropathy and that superficial reddening is rarely observed in patients with chronic liver disease as one of endoscopic findings of portal hypertensive gastropathy, it is concluded that superficial reddening on the surface of gastric rugae should not be included in the category of typical endoscopic findings of patients with portal hypertensive gastropathy.},
 pages = {121--126},
 title = {A Luminol-enhanced Chemiluminescence Study on the Gastric Mucosa with Portal Hypertensive Gastropathy},
 volume = {45},
 year = {1997}
}