@article{oai:niigata-u.repo.nii.ac.jp:00006396,
 author = {Sato, Yoshinobu and Farges, Olivier and Buffello, Delphine and Bismuth, Henri},
 issue = {3},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Sep},
 note = {We investigated the presence of autoreactive T and B cells, extrathymic T cells (intermediate TcR cells), natural killer (NK) marker-positive T cells, and CD5^+B cells in the liver of older rats. Results showed that lymphocyte function-associated antigen-1 (LFA-1)^<+++>CD3^+ cells, which have a phenotype similar to that of intermediate TcR cells of mice, increased in the liver, spleen, and peripheral blood of older rats (55 weeks and 64 weeks of age) compared with young, normal rats. Conversely, LFA-1^<++>CD3^+ cells decreased in older rats. The LFA-1^<+++>CD3^+ cells displayed an intermediate staining intensity for CD3 compared with that of LFA-1^<++>CD3^+ cells and they seemed similar to extrathymic T cells in mice. However, the LFA-1^<+++> CD3^+ cells were almost all CD8^+, in contrast to those of mice. Double negative (DN) CD^<4->CD^<8->T cells comprised less than 1% of the T-cell population in rats. NK3.2.3^<++> T cells also increased in the liver, but not in the peripheral blood of older rats; conversely, NK cells decreased in older rats. CD5^+ B cells increased in the liver but not in the spleen and peripheral blood of older rats. Furthermore, class II positive T cells and interleukin-2 receptor (IL-2R) positive T cells increased in the liver of older rats. These results suggest that T cells with a phenotype similar to the extrathymic T cells of mice are present in the rat liver.},
 pages = {107--114},
 title = {Detection of Intermediate TcR Cells, NK3.2.3-positive T Cells, and CD5^+B Cells in Older Rats},
 volume = {45},
 year = {1997}
}