@article{oai:niigata-u.repo.nii.ac.jp:00006390, author = {Cui, Xing}, issue = {4}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Dec}, note = {The effects of the oral administration of ginseng extract (GE, the root of panax ginseng C. A. Meyer) and its constituents (GRG, ginsenoside-Rg_1 and GRB, ginsenoside-Rbl_1) on liver regeneration were examined in 66% hepatectmized rats. When liver regeneration was evaluated by the mitotic index of the hepatocyte (MI), a significant increase in the MI was observed 2 and 3 days after GE administration, and the MI response was dose-dependent. Food intake was not affected by GE administration, nor there was any change in the serum insulin concentration. It was also noted that the oral administration of GRG produced a MI response similar to that caused by GE administration. Serum parameters indicating liver and kidney function were unchanged after GE administration. These observations lead us to conclude that orally administered GE and its specific constituent are capable of stimulating liver regeneration without serious systemic effects.}, pages = {161--166}, title = {Orally Administered Ginseng Extract Stimulates Liver Regeneration in Partially Hepatectomized Rats}, volume = {45}, year = {1997} }