@article{oai:niigata-u.repo.nii.ac.jp:00006370, author = {Sakaguchi, Takeo and Nishimura, Atsushi and Cui, Xing and Aono, Takashi}, issue = {3}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Sep}, note = {The plasma disappearance curve of indocyanine green (ICG) was estimated for 15 min by a non-invasive serial monitoring system following electrical stimulation of the hepatic vagal branch in anesthetized rats. The stimulation parameters were 6 V, 1 ms width (square wave for 6 min) and 10 Hz. When ICG 0.25 mg/kg (200 μl) was injected into the jugular vein as a bolus, the curve for ICG was obtained; this was shifted downwards by the electrical stimulation of the hepatic vagal branch. The magnitude of ICG response due to stimulation tended to be frequency dependent. No appreciable change in systemic arterial pressure or portal venous blood flow was seen during the ICG estimation. These results suggest that the hepatic vagal branch contains signals which directly modify the uptake of ICG by the hepatocytes without hepatic circulatory influence.}, pages = {89--92}, title = {Plasma Indocyanine Green Disappearance Induced by Electrical Stimulation of the Hepatic Vagal Branch in Rats}, volume = {46}, year = {1998} }