@article{oai:niigata-u.repo.nii.ac.jp:00006366, author = {Murakami, Hiroshi and Sakai, Yasuo and Ohta, Kazutoshi and Hatakeyama, Katsuyoshi}, issue = {4}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Dec}, note = {Two fatty acid binding proteins, liver and intestinal, have been identified in the rat intestine. Both are thought to be closely related to the absorption and metabolism of fatty acids in the intestinal epithelium. However, the underlying mechanism is not clearly understood. The purpose of this study was therefore to investigate the roles of these two fatty acid binding proteins in the intestinal absorption of fatty acids. Rats were fed diets varying in fat content for two or four weeks. Liver and intestinal fatty acid binding proteins were extracted from the duodenum, jejunum and ileum, and their concentrations were measured using the single radial immunodiffusion method. Rats fed with a high fat diet for two weeks had a significantly increased liver fatty acid binding protein concentration in the jejunum, and a significantly increased intestinal fatty acid binding protein concentration in both the jejunum and the ileum in comparison with the duodenum. Rats fed a high fat diet for four weeks also had a significantly increased liver fatty acid binding protein concentration in the jejunum, and a significantly increased intestinal fatty acid binding protein concentration in the ileum compared with that in the duodenum. Since the increase in the concentrations of liver and intestinal fatty acid binding proteins varied depending on the amount of fat, we speculate that liver and intestinal fatty acid binding proteins possess different mechanisms in the absorption and metabolism of fatty acids.}, pages = {147--152}, title = {Dietary Fat Content Effects on Concentrations of Liver and Intestinal Fatty Acid Binding Proteins}, volume = {46}, year = {1998} }