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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.46 No.4

Mechanism of Antitumor Effect Mediated by In Vitro Activated Tumor-draining Lymph Node Cells

http://hdl.handle.net/10191/33090
http://hdl.handle.net/10191/33090
6c31848b-999a-499a-88ac-58cdfee48aaa
名前 / ファイル ライセンス アクション
46(4)_121-131.pdf 46(4)_121-131.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-21
タイトル
タイトル Mechanism of Antitumor Effect Mediated by In Vitro Activated Tumor-draining Lymph Node Cells
タイトル
言語 en
タイトル Mechanism of Antitumor Effect Mediated by In Vitro Activated Tumor-draining Lymph Node Cells
言語
言語 eng
キーワード
主題Scheme Other
主題 adoptive immunotherapy
キーワード
主題Scheme Other
主題 peritoneal cavity
キーワード
主題Scheme Other
主題 macrophages
キーワード
主題Scheme Other
主題 GdCl_3
キーワード
主題Scheme Other
主題 IFN-γ
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Maruyama, Yoshie

× Maruyama, Yoshie

WEKO 52555

Maruyama, Yoshie

Search repository
Yoshizawa, Hirohisa

× Yoshizawa, Hirohisa

WEKO 52556

Yoshizawa, Hirohisa

Search repository
Arakawa, Masaaki

× Arakawa, Masaaki

WEKO 52557

Arakawa, Masaaki

Search repository
抄録
内容記述タイプ Abstract
内容記述 We previously demonstrated that tumorspecific effector cells could be generated from tumordraining lymph node cells by in vitro sequential activation with anti-CD3 mAb and IL-2. In the present study, we further examined cellular interactions and mechanisms of the antitumor effect. Tumor-draining lymph node cells (TDLN) of a weakly immunogenic fibrosarcoma, MCA 205, were activated by the anti-CD3/IL-2 method and transferred into the peritoneal cavities of mice bearing 5-day established peritoneal dissemination of MCA 205 tumor cells. Intraperitoneal injection of anti-CD3/IL-2-activated TDLN significantly prolonged the survival period, and 80% of treated mice remained tumor free for more than 80 days. In vivo depletion of host macrophages with GdCI_3 clearly abrogated the antitumor effect, while the elimination of host T cells with sublethal irradiation (500 R) did not, indicating that host macrophages are indispensable in the antitumor effect. In vitro cytotoxicity and cell proliferation were further examined in detail to determine the commitment of macrophages and mediator cytokines. Although anti-CD3/IL-2 activated cells mediated minimal cytotoxicity in a 4-hr ^<51>Cr releasing assay, tumor specific cytolytic action was detected in an 18-hr assay with coexisting peritoneal cells. The results suggest that peritoneal macrophages play an indispensable role in this treatment effect and that T cell-macrophage interactions were mediated by IFN-γ, the importance of which was exhibited in the early phase of the tumor-effector-macrophage contact.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 46, 号 4, p. 121-131, 発行日 1998-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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