{"created":"2021-03-01T06:10:15.782330+00:00","id":6360,"links":{},"metadata":{"_buckets":{"deposit":"e2b29d0d-7da4-4bf1-ab7a-b9a3d8c26bb0"},"_deposit":{"id":"6360","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6360"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006360","sets":["453:456","471:537:568:608"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"25","bibliographicPageStart":"21","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been shown that mice such as AKR/J (H-2^k), C3H/He (H-2^k), CBA/J (H-2^k), DBA/1 (H-2^q) and DBA/2 (H-2^d) are susceptible to Ehrlich ascites tumor (EAT), while other mice such as A/J (H-2^a), BALB/c (H-2^d), C57BL/6(H-2^b), C57BL/10(H-2^b), NZB/N(H-2^d) and SJL (H-2^s) are resistant to EAT. In addition, Ly haplotypes of the former EAT-progressive mouse strains classified were Ly-1^a (except AKR) and Ly-2^a, and those of the latter EAT-regressive mouse strains displayed Ly-1^b and Ly-2^b as common features. To see how the shift restricted in H-2 or in Ly haplotype affects their susceptibility, EAT progression in H-2 congenic and in Ly congenic mice was compared with that in standard mice. The results are as follows. 1) B10(H-2^b) as a standard was EAT-regressive. B10. D2(H-2^d), which is H-2 congenic between B10(H-2^b) and DBA/2(H-2^d), was EAT-regressive, although the H-2 locus of B10 shifted to the haplotype d of DBA/2. DBA/2 itself is EAT-progressive. This indicates that at least H-2K and/or D loci as class I are not simply related to mouse strain susceptibility to EAT. B10.Y (H-2^<pa>) was EAT-regressive. B10.R III (H-2^r) was almost EAT-regressive with some individual variations. B10.BR (H-2^k) and B10.SM (H-2^v) were EAT-progressive. In short, a shift in H-2 haplotype from b to k or b to v is significant in changing B10 susceptibility to EAT. 2) B6(H-2^b, Ly-1^b, Ly-2^b) as a standard was EAT-regressive. B6-Ly-1^a (H-2^b, Ly-1^a, Ly-2^b), B6-Ly-2^a (H-2^b, Ly-1^b, Ly-2^a) and B6-Ly-2^a, 3^a (H-2^b, Ly-1^b, Ly-2^a, Ly-3^a) were all EAT-regressive. No change in susceptibility was produced by the Ly-1,2,3,haplotype shift. Other B6 congenic mice such as B6-Tla^a (H-2K^k・D^b) and B6.C-H-2^<bm12>(H-2Aβ : bm12) were also EAT-regressive. From the results, it is concluded that H-2K, D loci including the TL region as class I, I-Aβ subregion as class II or Ly-1,2,3 loci, are not simply related to mouse strain susceptibility to EAT, suggesting the participation of non-MHC genes under H-2 associated control.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATO, Norimitsu L."}],"nameIdentifiers":[{"nameIdentifier":"52543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KATO, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"52544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUJISAWA, Nobuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"52545","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00000007196.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000007196.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6360/files/KJ00000007196.pdf"},"version_id":"7ebb7464-4e7f-4a4f-9ee3-0942025e71e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"H-2 congenic mice","subitem_subject_scheme":"Other"},{"subitem_subject":"Ly congenic mice","subitem_subject_scheme":"Other"},{"subitem_subject":"Ehrlich tumor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors"},{"subitem_title":"Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","608"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6360","relation_version_is_last":true,"title":["Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:41.184000+00:00"}