{"_buckets": {"deposit": "e2b29d0d-7da4-4bf1-ab7a-b9a3d8c26bb0"}, "_deposit": {"id": "6360", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6360"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006360"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "25", "bibliographicPageStart": "21", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "It has been shown that mice such as AKR/J (H-2^k), C3H/He (H-2^k), CBA/J (H-2^k), DBA/1 (H-2^q) and DBA/2 (H-2^d) are susceptible to Ehrlich ascites tumor (EAT), while other mice such as A/J (H-2^a), BALB/c (H-2^d), C57BL/6(H-2^b), C57BL/10(H-2^b), NZB/N(H-2^d) and SJL (H-2^s) are resistant to EAT. In addition, Ly haplotypes of the former EAT-progressive mouse strains classified were Ly-1^a (except AKR) and Ly-2^a, and those of the latter EAT-regressive mouse strains displayed Ly-1^b and Ly-2^b as common features. To see how the shift restricted in H-2 or in Ly haplotype affects their susceptibility, EAT progression in H-2 congenic and in Ly congenic mice was compared with that in standard mice. The results are as follows. 1) B10(H-2^b) as a standard was EAT-regressive. B10. D2(H-2^d), which is H-2 congenic between B10(H-2^b) and DBA/2(H-2^d), was EAT-regressive, although the H-2 locus of B10 shifted to the haplotype d of DBA/2. DBA/2 itself is EAT-progressive. This indicates that at least H-2K and/or D loci as class I are not simply related to mouse strain susceptibility to EAT. B10.Y (H-2^\u003cpa\u003e) was EAT-regressive. B10.R III (H-2^r) was almost EAT-regressive with some individual variations. B10.BR (H-2^k) and B10.SM (H-2^v) were EAT-progressive. In short, a shift in H-2 haplotype from b to k or b to v is significant in changing B10 susceptibility to EAT. 2) B6(H-2^b, Ly-1^b, Ly-2^b) as a standard was EAT-regressive. B6-Ly-1^a (H-2^b, Ly-1^a, Ly-2^b), B6-Ly-2^a (H-2^b, Ly-1^b, Ly-2^a) and B6-Ly-2^a, 3^a (H-2^b, Ly-1^b, Ly-2^a, Ly-3^a) were all EAT-regressive. No change in susceptibility was produced by the Ly-1,2,3,haplotype shift. Other B6 congenic mice such as B6-Tla^a (H-2K^k\u30fbD^b) and B6.C-H-2^\u003cbm12\u003e(H-2A\u03b2 : bm12) were also EAT-regressive. From the results, it is concluded that H-2K, D loci including the TL region as class I, I-A\u03b2 subregion as class II or Ly-1,2,3 loci, are not simply related to mouse strain susceptibility to EAT, suggesting the participation of non-MHC genes under H-2 associated control.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SATO, Norimitsu L."}], "nameIdentifiers": [{"nameIdentifier": "52543", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KATO, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "52544", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FUJISAWA, Nobuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "52545", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "filename": "KJ00000007196.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 23000000, "url": {"label": "KJ00000007196.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6360/files/KJ00000007196.pdf"}, "version_id": "7ebb7464-4e7f-4a4f-9ee3-0942025e71e9"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "H-2 congenic mice", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ly congenic mice", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ehrlich tumor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors"}, {"subitem_title": "Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/608"], "permalink_uri": "http://hdl.handle.net/10191/1942", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6360", "relation": {}, "relation_version_is_last": true, "title": ["Susceptibility of H-2 and Ly Congenic Mice to Ehrlich Ascites Tumors"], "weko_shared_id": null}