@article{oai:niigata-u.repo.nii.ac.jp:00006359,
 author = {CUI, Xing and SAKAGUCHI, Takeo and OHTAKE, Masahiro and SHIRAI, Yoshio and HATAKEYAMA, Katsuyoshi},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {Platelet counts and serum cholesterol levels in the blood were examined after oral administration of ginseng extract (GE) to 66% hepatectomized rats. A significant decrease in the platelet count (PC) and adhesiveness (PA) was obtained 3 days after hepatectomy when GE 125 mg/kg/day was administered, and the PA reduction was dose dependent in the range of 0-250 mg/kg/day. The serum concentration of total cholesterol was also decreased by the GE administration, but food intake was unaffected. Serum parameters indicating liver and kidney functions were unchanged after GE administration except for lipid metabolic parameters. Because enhanced PC and PA in the presence of hypercholesterolemia are apt to lead to thromboembolism after major abdominal surgery, these results suggest that orally administered GE is capable of preventing the thromboembolic tendency associated with major hepatic surgery.},
 pages = {15--19},
 title = {Platelet and Cholesterol Responses Caused by Oral Administration of Ginseng Extract in 66% Hepatectomized Rats},
 volume = {47},
 year = {1999}
}