@article{oai:niigata-u.repo.nii.ac.jp:00006341,
 author = {OHTAKE, Masahiro and CUI, Xing and SAKAGUCHI, Takeo and ISHIZUKA, Dai and MARUTA, Tomoaki and MAKINO, Shigeto and SHIRAI, Yoshio and HATAKEYAMA, Katsuyoshi},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {Portal venous blood flow (PVF), hepatic arterial blood flow (HAF), and systemic arterial pressure (SAP) were examined after prostaglandin E_1 (PGE) injection into the jugular vein under variably enhanced intraabdominal pressure (IAP) in pigs. The IAP was controlled by carbon dioxide pneumoperitoneum. When IAP was increased to 8 or 12 mmHg, PVF was reduced but HAF and SAP were unchanged. In this IAP condition the injection of PGE at 0.25 μg/kg/min for 2 min produced an increase in PVF without causing any change in HAF or SAP. The response in PVF was dose-dependent. When IAP was increased to 16 mmHg, PVF and HAF were reduced without any change in SAP. In such a case, no noticeable changes in PVF, HAF, or SAP were seen with the same dose of PGE. These results suggest that PGE is effective in increasing PVF in an enhanced IAP condition, but such circulatory improvement due to PGE appears limited to IAP at about less than 12 mmHg.},
 pages = {147--153},
 title = {Suppression of Liver Blood Flow by Carbon Dioxide Pneumoperitoneumcan be Improved by Prostaglandin E_1 in Pigs},
 volume = {47},
 year = {1999}
}