{"created":"2021-03-01T06:10:13.044026+00:00","id":6317,"links":{},"metadata":{"_buckets":{"deposit":"04a76329-fd4d-4c52-8648-2b3256a4ff19"},"_deposit":{"id":"6317","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6317"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006317","sets":["453:456","471:537:568:601"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"125","bibliographicPageStart":"119","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The intercellular adhesion molecule-1 (ICAM-1) is expressed on the surface of endothelial cells as well as neutrophils. Because neutrophils in the coronary circulation may play an important role in the progression of coronary artery disease, ICAM-1 and other adhesion molecules expressed on them were studied in the coronary circulation of patients with coronary artery disease. We used flow cytofluorometry to evaluate the amount of ICAM-1,CD18,and L-selectin expressed on neutrophils entering and leaving the coronary circulation in 18 patients who underwent coronary angiography. In addition, the serum level of the circulating form of ICAM-1 (cICAM-1) was measured in the same samples by using an enzyme-linked immunosorbent assay. Expression as the percentage of change between the left coronary artery and coronary sinus showed that neutrophil ICAM-1 (nICAM-1) decreased and serum cICAM-1 increased in patients with severe left coronary artery stenosis, compared with those with angiographically normal coronary arteries or only mild stenosis (nICAM-1,-9.7±2.9% vs 1.0±4.0%, p<0.05; cICAM-1,6.3±1.9% vs 0.5±1.7%, p<0.05,respectively). The changes in the expression of CD18 and L-selectin on neutrophils passing through the coronary circulation were not significant (CD18,-3.1±2.0% vs -3.8±4.3%; L-selectin, 6.0±3.6% vs -1.5±4.5%, respectively). ICAM-1 expressed on neutrophils appeared to be digested and relesed into plasma during passage through the coronary circulation in patients with severe stenotic coronary arteries. Thus, measurements of ICAM-1 may allow a prediction of the progression of coronary atherosclerosis.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HIGUCHI, Kotaro"}],"nameIdentifiers":[{"nameIdentifier":"52315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MATSUBARA, Taku"}],"nameIdentifiers":[{"nameIdentifier":"52316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TOBA, Ken"}],"nameIdentifiers":[{"nameIdentifier":"52317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HORI, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"52318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IDA, Toru"}],"nameIdentifiers":[{"nameIdentifier":"52319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAKEMOTO, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"52320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAMURA, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"52321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAZOE, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"52322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OITE, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"52323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"AIZAWA, Yoshifusa"}],"nameIdentifiers":[{"nameIdentifier":"52324","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00000007272.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000007272.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6317/files/KJ00000007272.pdf"},"version_id":"501abc1d-745a-42ab-910c-24dea23eb162"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ICAM-1","subitem_subject_scheme":"Other"},{"subitem_subject":"coronary artery disease","subitem_subject_scheme":"Other"},{"subitem_subject":"coronary circulation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Alterations in the Expression of Intercellular Adhesion Molecule-1(ICAM-1) on Neutrophils and in the Serum in the Coronary Circulationof Patients with Coronary Artery Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Alterations in the Expression of Intercellular Adhesion Molecule-1(ICAM-1) on Neutrophils and in the Serum in the Coronary Circulationof Patients with Coronary Artery Disease"},{"subitem_title":"Alterations in the Expression of Intercellular Adhesion Molecule-1(ICAM-1) on Neutrophils and in the Serum in the Coronary Circulationof Patients with Coronary Artery Disease","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","601"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6317","relation_version_is_last":true,"title":["Alterations in the Expression of Intercellular Adhesion Molecule-1(ICAM-1) on Neutrophils and in the Serum in the Coronary Circulationof Patients with Coronary Artery Disease"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:38.540446+00:00"}