@article{oai:niigata-u.repo.nii.ac.jp:00006316,
 author = {WATANABE, Kenichi and OHTA, Yoshimi and MA, Meilei and INOUE, Mikio and SAITO, Yuki and KOTAKE, Miho and WAHED, Mir I I and TAKAI, Reiko and KODAMA, Makoto and HANAWA, Haruo and ITO, Masahiro and FUSE, Koichi and TANABE, Naohito and KATO, Kiminori and HIRONO, Satoru and NAGATOMO, Takafumi and AIZAWA, Yoshifusa},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {This study examined the effects of cisapride, a 5-HT_4 receptor agonist, on the QT interval in rats, and evaluated whether mexiletine, a potent antiarrhythmic drug, could prevent a cisapride-induced prolongation of the QT interval. The effects of drugs on electrocardiograms in anesthetized normal Lewis and heart failure rats were evaluated. The effects of cisapride were investigated by administering three different dosages (8,16 and 24mg/kg) for the acute study and one dosage (24mg/kg/day) for the chronic study (for 7 days) in control and ailing rats. After the oral administration of mexiletine at 30mg/kg for 1 week, cisapride at 24mg/kg was administered to the rats with heart failure (n=15 in each). After chronic cisapride treatment for 7 days, the QT intervals in control and ailing rats were prolonged from 68.0±1.6 (mean±s.e.m.) to 74.0±2.4msec and from 77.6±1.9 to 88.8±2.3 msec, respectively (p<0.05 and p<0.01). A single dosage of cisapride at 8 or 16 mg/kg did not affect the QT interval in control rats. However, with a single dose of cisapride at 8,16 and 24mg/kg in rats with heart failure, the QT interval increased dose-dependently from 75.5±1.9 to 81.2±1.8msec, 76.4±1.6 to 87.8±2.5msec, and 78.4±2.1 to 101.4±1.2msec, respectively (each, p<0.01). After the administration of mexiletine, cisapride had no such effects. Cisapride prolonged the QT interval in rats with heart failure dose-dependently, while mexiletine prevented the effect. These results indicate that a high dose of cisapride should be used carefully during illness, but mexiletine may prevent a cisapride-induced long QT interval.},
 pages = {113--117},
 title = {Effects of Cisapride and Protective Effects of Mexiletine on the QT Interval in Rats},
 volume = {48},
 year = {2000}
}