ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "704cf0c8-4ed1-499d-a0c7-76870109b53c"}, "_deposit": {"id": "6274", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6274"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006274", "sets": ["456", "593"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "30", "bibliographicPageStart": "25", "bibliographicVolumeNumber": "51", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Object: We have recently cloned cDNA of human neuronatin. Northern blot and RT-PCR analyses revealed that mRNA are expressed in the fetal brain, adult anterior pituitary gland, and pituitary adenomas, but they are hardly detected in the adult brain and brain tumors. To clarify the role of this gene, we investigated the cellular localization of neuronatin mRNA using in situ hybridization (ISH). Methods: ISH and immunohistochemistry (IHC) were performed on serial frozen sections of three normal pituitary glands and tumors (10 GH-omas, 5 PRL-omas, 2 ACTH-omas, 10 nonfunctioning adenomas, 3 craniopharyngiomas, and 1 Rathke\u0027s cleft cyst). In ISH, a radiolabelled oligonucleotide probe for neuronatin was used. In IHC, antibodies to GH, PRL, FSH-beta, LH-beta, TSH-beta, and ACTH were used. Results: 1) Neuronatin mRNA was detected in the anterior pituitary gland, but not in the posterior gland; 2) Neuronatin expression was also observed in various pituitary adenomas and epithelial cells of Rathke\u0027s cleft cyst, but hardly detected in craniopharyngiomas; 3) In pituitary adenomas, neuronatin expression was seen irrespective of hormone productivity of each cell; Discussion: 1) Neuronatin is thought to participate in the development, differentiation, or maintenance of the pituitary gland and pituitary adenomas, though it is not involved in hormone productivity; 2) Information about the distribution of neuronatin may facilitate an understanding of the origin of pituitary tumors, including craniopharyngiomas and Rathke\u0027s cleft cysts.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ONO, Hideko"}], "nameIdentifiers": [{"nameIdentifier": "52066", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MORII, Ken"}], "nameIdentifiers": [{"nameIdentifier": "52067", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAMURA, Tetsuro"}], "nameIdentifiers": [{"nameIdentifier": "52068", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TANAKA, Ryuichi"}], "nameIdentifiers": [{"nameIdentifier": "52069", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000007357.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "KJ00000007357.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6274/files/KJ00000007357.pdf"}, "version_id": "946e471b-d274-4ebd-9ff7-a63800a1d1be"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "neuronatin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "in situ hybridization", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunohistochemistry", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pituitary tumors", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "In situ Hybridization Analysis of Neuronatin mRNA in the Human Pituitary Gland and Pituitary Tumors", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "In situ Hybridization Analysis of Neuronatin mRNA in the Human Pituitary Gland and Pituitary Tumors"}, {"subitem_title": "In situ Hybridization Analysis of Neuronatin mRNA in the Human Pituitary Gland and Pituitary Tumors", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "593"], "permalink_uri": "http://hdl.handle.net/10191/1882", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6274", "relation": {}, "relation_version_is_last": true, "title": ["In situ Hybridization Analysis of Neuronatin mRNA in the Human Pituitary Gland and Pituitary Tumors"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.51 No.1

In situ Hybridization Analysis of Neuronatin mRNA in the Human Pituitary Gland and Pituitary Tumors

http://hdl.handle.net/10191/1882
http://hdl.handle.net/10191/1882
b9ecda28-3156-4213-b266-797bc71d0210
名前 / ファイル ライセンス アクション
KJ00000007357.pdf KJ00000007357.pdf (2.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル In situ Hybridization Analysis of Neuronatin mRNA in the Human Pituitary Gland and Pituitary Tumors
タイトル
言語 en
タイトル In situ Hybridization Analysis of Neuronatin mRNA in the Human Pituitary Gland and Pituitary Tumors
言語
言語 eng
キーワード
主題Scheme Other
主題 neuronatin
キーワード
主題Scheme Other
主題 in situ hybridization
キーワード
主題Scheme Other
主題 immunohistochemistry
キーワード
主題Scheme Other
主題 pituitary tumors
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 ONO, Hideko

× ONO, Hideko

WEKO 52066

ONO, Hideko

Search repository
MORII, Ken

× MORII, Ken

WEKO 52067

MORII, Ken

Search repository
TAMURA, Tetsuro

× TAMURA, Tetsuro

WEKO 52068

TAMURA, Tetsuro

Search repository
TANAKA, Ryuichi

× TANAKA, Ryuichi

WEKO 52069

TANAKA, Ryuichi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Object: We have recently cloned cDNA of human neuronatin. Northern blot and RT-PCR analyses revealed that mRNA are expressed in the fetal brain, adult anterior pituitary gland, and pituitary adenomas, but they are hardly detected in the adult brain and brain tumors. To clarify the role of this gene, we investigated the cellular localization of neuronatin mRNA using in situ hybridization (ISH). Methods: ISH and immunohistochemistry (IHC) were performed on serial frozen sections of three normal pituitary glands and tumors (10 GH-omas, 5 PRL-omas, 2 ACTH-omas, 10 nonfunctioning adenomas, 3 craniopharyngiomas, and 1 Rathke's cleft cyst). In ISH, a radiolabelled oligonucleotide probe for neuronatin was used. In IHC, antibodies to GH, PRL, FSH-beta, LH-beta, TSH-beta, and ACTH were used. Results: 1) Neuronatin mRNA was detected in the anterior pituitary gland, but not in the posterior gland; 2) Neuronatin expression was also observed in various pituitary adenomas and epithelial cells of Rathke's cleft cyst, but hardly detected in craniopharyngiomas; 3) In pituitary adenomas, neuronatin expression was seen irrespective of hormone productivity of each cell; Discussion: 1) Neuronatin is thought to participate in the development, differentiation, or maintenance of the pituitary gland and pituitary adenomas, though it is not involved in hormone productivity; 2) Information about the distribution of neuronatin may facilitate an understanding of the origin of pituitary tumors, including craniopharyngiomas and Rathke's cleft cysts.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 51, 号 1, p. 25-30, 発行日 2003-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 19:42:24.380771
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3