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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.51 No.1

Investigation of the Transcription in C6 Cells Trapped by a Novel Gene Trap Vector of the Convergent Type

http://hdl.handle.net/10191/1874
http://hdl.handle.net/10191/1874
c7e0e77b-7f47-43f1-a60d-5d9fba8eb1d2
名前 / ファイル ライセンス アクション
KJ00000007355.pdf KJ00000007355.pdf (2.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Investigation of the Transcription in C6 Cells Trapped by a Novel Gene Trap Vector of the Convergent Type
タイトル
言語 en
タイトル Investigation of the Transcription in C6 Cells Trapped by a Novel Gene Trap Vector of the Convergent Type
言語
言語 eng
キーワード
主題Scheme Other
主題 gene trap
キーワード
主題Scheme Other
主題 convergent transcription
キーワード
主題Scheme Other
主題 overlap gene
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 KUTSUWADA, Chika

× KUTSUWADA, Chika

WEKO 52055

KUTSUWADA, Chika

Search repository
MIYASHITA, Akinori

× MIYASHITA, Akinori

WEKO 52056

MIYASHITA, Akinori

Search repository
SASAKI, Tamaki

× SASAKI, Tamaki

WEKO 52057

SASAKI, Tamaki

Search repository
ODANI, Shoji

× ODANI, Shoji

WEKO 52058

ODANI, Shoji

Search repository
KUWANO, Ryozo

× KUWANO, Ryozo

WEKO 52059

KUWANO, Ryozo

Search repository
抄録
内容記述タイプ Abstract
内容記述 The interference of transcription by antisense transcripts is now regarded as one of the regulatory mechanisms of gene expression. The overlapping of genes in opposite strands has recently attracted much attention because of their potential association with human diseases. The regulatory mechanism of the overlapping gene itself is also of considerable interest from the view point of gene expression. We designed a novel gene trap vector (GTV) that can be transcribed bidirectionally. It contained promoters, dual and orientation-specific reporter genes (β-galactosidase and green fluorescent protein), drug-resistant genes, and SV40 polyadenylation signal flanked by loxP sites. C6 cell lines stably integrated with the GTV were established by selection with antibiotics. Expression patterns of sense and antisense strands around the trap vector examined by the two reporter genes and their transcripts varied substantially by cell lines: some of this was attributable to interference by antisense transcription, but a portion seemed to be under the control of unknown mechanisms. These results proved the present GTV to be useful as a model system for the study of bidirectional transcription in gene expression.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 51, 号 1, p. 1-11, 発行日 2003-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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