@article{oai:niigata-u.repo.nii.ac.jp:00006261,
 author = {SHIBUYA, Michiko and ITO, Ryo and TAKIZAWA, Yoko and TANEIKE, Ikue and NAKAGAWA, Saori and IWAKURA, Nobuhiro and NAKAYAMA, Teruko and ANNO, Masato and YAGI, Yutaka and YAMAMOTO, Tatsuo},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {A Vibrio vulnificus infection occurred in Niigata in 2003. The patient was a 76-year-old male who had a medical history of diabetes, and was a heavy consumer of alcohol. He did not eat raw fish or shellfish before development of the symptoms, and the source of infection was unknown. The patient reported a disturbance in consciousness, and mild swelling of the lower leg was observed. The same V. vulnificus strains, as evidenced by pulsed-field gel electrophoresis, were isolated from venous blood and puncture fluid of the lower leg. White blood cells and platelets were decreased. The patient was treated with imipenem, but succumbed. The V. vulnificus strains were highly susceptible to the 3rd-generation cephems, carbapenems, tetracyclines, and fluoroquinolones. With respect to the tetracyclines and macrolides, the strains were most susceptible to minocycline and azithromycin, respectively. The strains were moderately resistant to the 1st- and the 2nd- generation cephems, kanamycin, streptomycin, roxithromycin, and fosfomycin. The V. vulnificus strains possessed a strong ability to adhere to and impair HCT-8 cells. In contrast to V. cholerae O1 or O139 and V. parahaemolyticus, the V. vulnificus strains had capsule-like wrinkles on the bacterial cell surface and occasionally exhibited a spiral-shaped body. These may be a cause, at least in part, of the invasive nature of the bacteria and fulminant development of the symptoms. Establishment of a rapid diagnosis is imperative.},
 pages = {149--156},
 title = {Occurrence of a Vibrio vulnificus Infection in Niigata in 2003},
 volume = {51},
 year = {2003}
}