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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.52 No.1

T Cell-mediated Induction of Anti-GBM Glomerulonephritis in WKY Rats

http://hdl.handle.net/10191/1818
http://hdl.handle.net/10191/1818
eb6fbf96-9382-42e9-b0e9-6f515b0986dd
名前 / ファイル ライセンス アクション
KJ00004267743.pdf KJ00004267743.pdf (4.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル T Cell-mediated Induction of Anti-GBM Glomerulonephritis in WKY Rats
タイトル
言語 en
タイトル T Cell-mediated Induction of Anti-GBM Glomerulonephritis in WKY Rats
言語
言語 eng
キーワード
主題Scheme Other
主題 T cell receptor αβ
キーワード
主題Scheme Other
主題 anti-GBM glomerulonephritis
キーワード
主題Scheme Other
主題 CD8^- T cells
キーワード
主題Scheme Other
主題 WKY rat
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 MATSUKI, Asako

× MATSUKI, Asako

WEKO 51929

MATSUKI, Asako

Search repository
FUJINAKA, Hidehiko

× FUJINAKA, Hidehiko

WEKO 51930

FUJINAKA, Hidehiko

Search repository
QU, Zhenylin

× QU, Zhenylin

WEKO 51931

QU, Zhenylin

Search repository
ZOU, Jun

× ZOU, Jun

WEKO 51932

ZOU, Jun

Search repository
EL-SHEMI, Adel Galal Ahmed

× EL-SHEMI, Adel Galal Ahmed

WEKO 51933

EL-SHEMI, Adel Galal Ahmed

Search repository
KOVALENKO, Pavel

× KOVALENKO, Pavel

WEKO 51934

KOVALENKO, Pavel

Search repository
YOSHIDA, Yutaka

× YOSHIDA, Yutaka

WEKO 51935

YOSHIDA, Yutaka

Search repository
YAOITA, Eishin

× YAOITA, Eishin

WEKO 51936

YAOITA, Eishin

Search repository
WILSON, Curtis B.

× WILSON, Curtis B.

WEKO 51937

WILSON, Curtis B.

Search repository
YAMAMOTO, Tadashi

× YAMAMOTO, Tadashi

WEKO 51938

YAMAMOTO, Tadashi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Glomerulonephritis induced in Wistar Kyoto (WKY) rats by the intravenous administration of rabbit anti-glomerular basement membrane antibody is characterized by a glomerular accumulation of T lymphocytes and monocytes/macrophages, crescent formation, and massive proteinuria. Although this model was initiated by the antibody injection, the involvement of cell-mediated immunity was also suggested since a crucial role of CD8-positive T lymphocytes was demonstrated in the induction of this model. An implication of humoral and cell-mediated immunity in this model was examined in the present study. The glomerular lesions and urinary protein excretion were deteriorated in rats preimmunized with rabbit IgG or inoculated with rabbit IgG-sensitized rat lymphocytes before the glomerular basement membrane (anti-GBM) antibody administration. In contrast, the anti-GBM glomerulonephritis was ameliorated by the passive transfer of a rat anti-rabbit IgG antibody. These observations suggested that cell-mediated immunity advanced the disease and humoral immunity suppressed it. We then examined the involvement of T cell receptor αβ on T lymphocytes by administrating a monoclonal antibody against the receptor (R73) in rats before or after the anti-GBM antibody injection. Pretreatment with the antibody markedly suppressed the glomerular lesion and proteinuria. However, the suppressive effect was minimal in rats given the antibody after the anti-GBM antibody injection. These results showed that the anti-GBM nephritis in WKY rats was mediated by T cell receptor αβ to initiate cell-mediated immunity.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 52, 号 1, p. 11-20, 発行日 2004-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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