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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.55 No.1

Glomerular Podocytes Express Protocadherin 17

http://hdl.handle.net/10191/5240
http://hdl.handle.net/10191/5240
573009b6-8d4b-41a2-a77e-7dfe52521a66
名前 / ファイル ライセンス アクション
17_0013.pdf 17_0013.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2008-04-08
タイトル
タイトル Glomerular Podocytes Express Protocadherin 17
タイトル
言語 en
タイトル Glomerular Podocytes Express Protocadherin 17
言語
言語 eng
キーワード
主題Scheme Other
主題 cadherin
キーワード
主題Scheme Other
主題 kidney
キーワード
主題Scheme Other
主題 glomerular epithelial cell
キーワード
主題Scheme Other
主題 podocyte
キーワード
主題Scheme Other
主題 protocadherin 17
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Takata, Takuma

× Takata, Takuma

WEKO 51621

Takata, Takuma

Search repository
Yaoita, Eishin

× Yaoita, Eishin

WEKO 51622

Yaoita, Eishin

Search repository
Kamiie, Junichi

× Kamiie, Junichi

WEKO 51623

Kamiie, Junichi

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Li, Huiping

× Li, Huiping

WEKO 51624

Li, Huiping

Search repository
Fujinaka, Hidehiko

× Fujinaka, Hidehiko

WEKO 51625

Fujinaka, Hidehiko

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Yoshida, Yutaka

× Yoshida, Yutaka

WEKO 51626

Yoshida, Yutaka

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Gejyo, Fumitake

× Gejyo, Fumitake

WEKO 51627

Gejyo, Fumitake

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Yamamoto, Tadashi

× Yamamoto, Tadashi

WEKO 51628

Yamamoto, Tadashi

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抄録
内容記述タイプ Abstract
内容記述 During a search for cadherin-related molecules expressed in rat glomeruli by RT-PCR with degenerate primers, we have isolated cDNA encoding protocadherin 17 (Pcdh17) in addition to Fat1. Although Pcdh17 has been suggested to participate in cell-cell adhesion and cell sorting, little is known about its distribution and function. To elucidate the localization and expression of Pcdh17, ribonuclease protection assay and in situ hybridization were performed in the rat. Pcdh17 expression was detected distinctly in RNAs from the cerebrum, cerebellum, lung, but spleen but weakly in RNAs from the whole kidney. In the kidney, intense signals for Pcdh17 were found in glomerular RNAs, with only or weak signals at best in cortical and medullary RNAs. In situ hybridization showed that Pcdh17 was predominantly expressed by podocytes in the glomerulus. Pcdh17 were found to have two isoforms that differ in the length of the cytoplasmic domains. The expression level of both isoforms did not change in puromycin aminonucleoside nephrosis where slit diaphragms disappear and new junctional complexes are newly formed. In conclusion, Pcdh17 is expressed by podocytes, which may be involved in several types of their intercellular junctions.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 55, 号 1, p. 9-15, 発行日 2007-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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