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Glomerular Podocytes Express Protocadherin 17
http://hdl.handle.net/10191/5240
http://hdl.handle.net/10191/5240573009b6-8d4b-41a2-a77e-7dfe52521a66
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-04-08 | |||||
タイトル | ||||||
タイトル | Glomerular Podocytes Express Protocadherin 17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Glomerular Podocytes Express Protocadherin 17 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cadherin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | kidney | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glomerular epithelial cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | podocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protocadherin 17 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Takata, Takuma
× Takata, Takuma× Yaoita, Eishin× Kamiie, Junichi× Li, Huiping× Fujinaka, Hidehiko× Yoshida, Yutaka× Gejyo, Fumitake× Yamamoto, Tadashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | During a search for cadherin-related molecules expressed in rat glomeruli by RT-PCR with degenerate primers, we have isolated cDNA encoding protocadherin 17 (Pcdh17) in addition to Fat1. Although Pcdh17 has been suggested to participate in cell-cell adhesion and cell sorting, little is known about its distribution and function. To elucidate the localization and expression of Pcdh17, ribonuclease protection assay and in situ hybridization were performed in the rat. Pcdh17 expression was detected distinctly in RNAs from the cerebrum, cerebellum, lung, but spleen but weakly in RNAs from the whole kidney. In the kidney, intense signals for Pcdh17 were found in glomerular RNAs, with only or weak signals at best in cortical and medullary RNAs. In situ hybridization showed that Pcdh17 was predominantly expressed by podocytes in the glomerulus. Pcdh17 were found to have two isoforms that differ in the length of the cytoplasmic domains. The expression level of both isoforms did not change in puromycin aminonucleoside nephrosis where slit diaphragms disappear and new junctional complexes are newly formed. In conclusion, Pcdh17 is expressed by podocytes, which may be involved in several types of their intercellular junctions. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 55, 号 1, p. 9-15, 発行日 2007-03 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |