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Bcl11b Heterozygous Mice are Susceptible to N-methyl-N-nitrosourea-induced Thymic Lymphomas
http://hdl.handle.net/10191/5245
http://hdl.handle.net/10191/52452e353778-bba4-4396-a196-8c0b718e91b9
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-04-08 | |||||
タイトル | ||||||
タイトル | Bcl11b Heterozygous Mice are Susceptible to N-methyl-N-nitrosourea-induced Thymic Lymphomas | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Bcl11b Heterozygous Mice are Susceptible to N-methyl-N-nitrosourea-induced Thymic Lymphomas | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | susceptibility to lymphomas | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bcl11b | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | N-methyl-N-nitrosourea | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epigenetic inactivation | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Funada, Riko
× Funada, Riko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | N-methyl-N-nitrosourea (MNU) is an alkylating agent that can modify the guanine base in DNA.The mode of mutation induction differs from that of radiation, which generates large mutations such as chromosomal deletion and translocation. Our previous studies showed that Bcl11b is a tumor suppressor gene and that Bcl11b+/- heterozygous mice are susceptible to γ-ray induced thymic lymphomas. This study investigates whether or not the Bcl11b+/- genotype also provides susceptibility to MNU-induced thymic lymphomas. The results showed that loss of one copy of the Bcl11b gene contributed to lymphomagenesis, indicating that Bcl11b can suppress MNUinduction of thymic lymphomas. Interestingly, loss of the wild-type Bcl11b allele was not detected in those lymphomas, contrasting with the finding ofa high frequency of the loss in the γ-ray induced Bcl11b+/- thymic lymphomas. On the other hand, epigenetic inactivation of Bcl11b was observed in 74% (14/19) of the Bcl11b+/- lymphomas. This may be the main contributor to the loss of Bcl11b function and probably affects the elevation of lymphoma incidence and the shortening of the latency in Bcl11b+/- mice when MNU is administrated. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 55, 号 2, p. 55-60, 発行日 2007-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |