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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Primary cilia regulate mandibular development

http://hdl.handle.net/10191/50258
http://hdl.handle.net/10191/50258
8c8a8c9c-2a3b-4df9-90d3-df642b71f370
名前 / ファイル ライセンス アクション
h29ndk395.pdf 本文 (2.6 MB)
h29ndk395_a.pdf 要旨 (222.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-06-29
タイトル
タイトル Primary cilia regulate mandibular development
タイトル
言語 en
タイトル Primary cilia regulate mandibular development
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 一次繊毛は下顎の発生を制御する
著者 Kitamura, Atsushi

× Kitamura, Atsushi

WEKO 51300

Kitamura, Atsushi

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著者別名
識別子 51301
識別子Scheme WEKO
姓名 北村, 厚
抄録
内容記述タイプ Abstract
内容記述 The primary cilia play a critical role in many biological processes including bone and cartilage formation. Perturbations in the function of primary cilia are known to cause a wide spectrum of human diseases: the ciliopathies. Craniofacial dysmorphologies including mandibular deformity are often seen in patients with ciliopathies. Mandibular development is characterized by chondrogenesis and osteogenesis. However, it remains unclear whether the primary cilia are involved in mandibular development. To address this question, we generated mice with a mesenchymal deletion of ciliary protein, Ift88 (Ift88^<fl/fl>; Wnt1Cre) and Ofd1 (Ofd1^<fl>; Wnt1Cre). Both Ofd1and Ift88 mutant mice showed ectopic mandibular bone, which was found to be associated with the downregulation of Shh signaling. Unlike mandibular bone, Meckel’s cartilage showed different phenotypes between Ofd1^<fl>; Wnt1Cre and Ift88^<fl/fl>; Wnt1Cre mice. Bifurcated and enlarged Meckel’s cartilage were observed in the posterior mandible of Ofd1^<fl>; Wnt1Cre mice, whereas Ift88^<fl/fl>; Wnt1Cre mice exhibited enlarged Meckel’s cartilage in the entire mandible. Chondrogenesis and osteogenesis during mandibular development is thus regulated by the primary cilia, and each ciliary protein is likely to have a distinct role, depending on the regions.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 甲第4432号. 学位記番号: 新大院博(歯)甲第395号. 学位授与年月日: 平成30年3月23日
書誌情報 p. 1-29, 発行日 2018-03-23
出版者
出版者 新潟大学
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-03-23
学位授与番号
学位授与番号 13101甲第4432号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第395号
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