{"created":"2021-03-01T06:09:50.273765+00:00","id":5958,"links":{},"metadata":{"_buckets":{"deposit":"718669b1-05b4-4fa9-95b2-1a07222431ce"},"_deposit":{"id":"5958","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5958"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005958","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clinical Significance of Ribonucleotide Reductase M1 Expression in Patients with Intrahepatic Cholangiocarcinoma : Association with Gemcitabine Resistance"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-20","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-09-20"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】Gemcitabine（以下GEM）の代謝経路において，リボヌクレオチド還元酵素の調節サブユニットであるRibonucleotide Reductase M1（以下RRM1）はGEMの作用機序に重要な働きを示すkey molecularとされている．本研究の目的は，肝内胆管癌におけるRRM1発現を免疫組織化学にて検討し，GEM基盤の術前化学療法の効果とRRM1発現との関連を明らかにすることにある．【対象と方法】1992年1月から2012年12月までに当科で根治切除が施行された肝内胆管癌43例を対象とした．術前に高度局所進展のため根治切除が困難・不能と診断された4例に対して，GEM基盤の術前化学療法（GEM単剤2例，GEM+TS-1併用2例）を施行した．術前化学療法の治療効果はRECISTガイドラインに準じて判定した．RRM1発現は免疫組織化学により評価され，陽性または陰性に分類した．【結果】RRM1発現陽性は43例中27例（63%）であった．GEM基盤の術前化学療法が施行された4例全例で重篤な有害事象の発生はなく，化学療法前に立案していた術式の遂行が可能であった．術前化学療法を施行した4例中3例はRRM1発現陽性であり，腫瘍縮小率は11%，14%，25%であり，治療効果は安定（SD）と判定された．残り1例はRRM1発現陰性で，腫瘍縮小率は68%であり，部分奏功（PR）と判定された．【結論】GEM基盤の術前化学療法の効果はRRM1発現と関連していることが示唆される．高度局所進展を伴う肝内胆管癌に対するGEM基盤の術前化学療法は安全に施行でき，かつ立案術式を遂行可能であるため，十分に認容されるものである．","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第4362号. 学位記番号: 新大院博（医）甲第775号. 学位授与年月日: 平成29年9月20日","subitem_description_type":"Other"},{"subitem_description":"新潟医学会雑誌. 2015, 129(1), 21-28.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第775号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4362号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"51150","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Katada, Tomohiro"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堅田, 朋大"}],"nameIdentifiers":[{"nameIdentifier":"51149","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h29nmk775.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5958/files/h29nmk775.pdf"},"version_id":"b425d795-ecb5-48c2-9b8e-29d064864acb"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h29nmk775_a.pdf","filesize":[{"value":"190.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5958/files/h29nmk775_a.pdf"},"version_id":"60fded9a-082e-44aa-aa12-d6793e9b59af"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝内胆管癌","subitem_subject_scheme":"Other"},{"subitem_subject":"Gemcitabine","subitem_subject_scheme":"Other"},{"subitem_subject":"RRM1","subitem_subject_scheme":"Other"},{"subitem_subject":"術前化学療法","subitem_subject_scheme":"Other"},{"subitem_subject":"外科切除","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"肝内胆管癌におけるRibonucleotide Reductase M1発現の臨床学的意義 : Gemcitabine治療抵抗性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝内胆管癌におけるRibonucleotide Reductase M1発現の臨床学的意義 : Gemcitabine治療抵抗性"},{"subitem_title":"肝内胆管癌におけるRibonucleotide Reductase M1発現の臨床学的意義 : Gemcitabine治療抵抗性","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-07"},"publish_date":"2017-11-07","publish_status":"0","recid":"5958","relation_version_is_last":true,"title":["肝内胆管癌におけるRibonucleotide Reductase M1発現の臨床学的意義 : Gemcitabine治療抵抗性"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:39:14.045252+00:00"}