{"created":"2021-03-01T06:09:43.948316+00:00","id":5857,"links":{},"metadata":{"_buckets":{"deposit":"b67ad52c-530e-4359-98cb-05f878752bf3"},"_deposit":{"id":"5857","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5857"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005857","sets":["453:455","471:561:562"]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-23","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(0bjectives)Alternative splicing alters protein structure, localization and function and increases biological diversity in response to physiological and pathological stress conditions. We investigated how alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes changes in hearts under pathological\\nstress conditions. (Methods)The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes, in response to acute inflammation, pressure overload and hypoxia, was analyzed by quantitative RT-PCR in the hearts of experimental autoimmune myocarditis rats and myocarditis patients,monocrotaline pulmonary\\nhypertension rats and in cardiomyocytes cultured under hypoxic conditions.(Results) Large N2BA-titin, cytoplasmic CaMKIIδ and PGM1-binding ZASP/Cypher isoforms significantly increased in rat hearts with myocarditis and hypertrophy compared with normal hearts. Large N2BA-titin and  cytoplasmic CaMKIIδ isoforms also significantly increased in myocarditis patient hearts compared with those with DCM. In cardiomyocytes under hypoxic conditions,\\nPGM1-binding ZASP/Cypher isoforms significantly increased, but large\\nN2BA-titin and cytoplasmic CaMKIIδ isoforms decreased, compared with cells under normoxic conditions. (Conclusions) The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes was markedly modulated in hearts under\\npathological stress conditions and may be involved in adaptations to pathological changes.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第4269号. 学位記番号: 新大院博（医）甲第747号. 学位授与年月日: 平成29年3月23日","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第747号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4269号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Jiao, Shuang"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"焦, 爽"}],"nameIdentifiers":[{"nameIdentifier":"50993","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28nmk747.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5857/files/h28nmk747.pdf"},"version_id":"42e87d1c-1423-4850-b8f9-5b54a4442b05"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28nmk747_a.pdf","filesize":[{"value":"205.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5857/files/h28nmk747_a.pdf"},"version_id":"36bbd75b-7254-4e33-849f-d5819713e41b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"心筋炎","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋症","subitem_subject_scheme":"Other"},{"subitem_subject":"心肥大","subitem_subject_scheme":"Other"},{"subitem_subject":"選択的スプライシング","subitem_subject_scheme":"Other"},{"subitem_subject":"低酸素","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節."},{"subitem_title":"心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節.","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-13"},"publish_date":"2017-06-13","publish_status":"0","recid":"5857","relation_version_is_last":true,"title":["心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節."],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:39:06.811110+00:00"}