@misc{oai:niigata-u.repo.nii.ac.jp:00005857,
 author = {焦, 爽},
 month = {Mar},
 note = {(0bjectives)Alternative splicing alters protein structure, localization and function and increases biological diversity in response to physiological and pathological stress conditions. We investigated how alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes changes in hearts under pathological\nstress conditions. (Methods)The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes, in response to acute inflammation, pressure overload and hypoxia, was analyzed by quantitative RT-PCR in the hearts of experimental autoimmune myocarditis rats and myocarditis patients,monocrotaline pulmonary\nhypertension rats and in cardiomyocytes cultured under hypoxic conditions.(Results) Large N2BA-titin, cytoplasmic CaMKIIδ and PGM1-binding ZASP/Cypher isoforms significantly increased in rat hearts with myocarditis and hypertrophy compared with normal hearts. Large N2BA-titin and  cytoplasmic CaMKIIδ isoforms also significantly increased in myocarditis patient hearts compared with those with DCM. In cardiomyocytes under hypoxic conditions,\nPGM1-binding ZASP/Cypher isoforms significantly increased, but large\nN2BA-titin and cytoplasmic CaMKIIδ isoforms decreased, compared with cells under normoxic conditions. (Conclusions) The alternative splicing of titin, CaMKIIδ and ZASP/Cypher genes was markedly modulated in hearts under\npathological stress conditions and may be involved in adaptations to pathological changes., 学位の種類: 博士（医学）. 報告番号: 甲第4269号. 学位記番号: 新大院博（医）甲第747号. 学位授与年月日: 平成29年3月23日, 新大院博（医）甲第747号},
 title = {心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節.},
 year = {2017}
}