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Recent evidence has demonstrated that patients with chronic kidney disease (CKD) have an increased risk of developing acute kidney injury (AKI). The present study was conducted to evaluate the prevalence of CKD risk factors in patients who received cisplatin and to assess the correlation between CKD risk factors and cisplatin-induced AKI.\\nMethods : We retrospectively analyzed 84 patients treated with cisplatin combination chemotherapy for thoracic malignancies. AKI was defined as a decrease in the estimated glomerular filtration rate (eGFR) \u003e 25 % from base line, an increase in the serum creatinine (sCre) level of \u003e 0.3 mg/dl or ≥ 1.5 times the baseline level.\\nResults : Eighty of the 84 patients (95.2 %) had at least one risk factor for CKD. All enrolled patients received cisplatin with hydration, magnesium supplementation and mannitol. Cisplatin-induced AKI was observed in 18 patients (21.4 %). Univariate analysis revealed that cardiac disease and use of non-steroidal anti-inflammatory drugs (NSAIDs) were associated with cisplatin-induced nephrotoxicity (odds ratios [OR] 6 and 3.56, 95 % confidence intervals [CI] 1.21–29.87 and 1.11–11.39, p = 0.04 and p = 0.04, respectively). Multivariate analysis revealed that cisplatin nephrotoxicity occurred significantly more often in patients with both risk factors (OR 13.64, 95 % CI 1.11–326.83, p = 0.04). 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Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors.
http://hdl.handle.net/10191/47613
http://hdl.handle.net/10191/47613d93d889c-902d-4a3c-8f3e-493c4f8f00f9
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-09-11 | |||||
タイトル | ||||||
タイトル | Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cisplatin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nephrotoxicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic kidney disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute kidney injury | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析 | |||||
著者 |
Sato, Ko
× Sato, Ko |
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著者別名 | ||||||
識別子 | 50992 | |||||
識別子Scheme | WEKO | |||||
姓名 | 佐藤, 昂 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background : Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who received cisplatin combination chemotherapy. Recent evidence has demonstrated that patients with chronic kidney disease (CKD) have an increased risk of developing acute kidney injury (AKI). The present study was conducted to evaluate the prevalence of CKD risk factors in patients who received cisplatin and to assess the correlation between CKD risk factors and cisplatin-induced AKI.\nMethods : We retrospectively analyzed 84 patients treated with cisplatin combination chemotherapy for thoracic malignancies. AKI was defined as a decrease in the estimated glomerular filtration rate (eGFR) > 25 % from base line, an increase in the serum creatinine (sCre) level of > 0.3 mg/dl or ≥ 1.5 times the baseline level.\nResults : Eighty of the 84 patients (95.2 %) had at least one risk factor for CKD. All enrolled patients received cisplatin with hydration, magnesium supplementation and mannitol. Cisplatin-induced AKI was observed in 18 patients (21.4 %). Univariate analysis revealed that cardiac disease and use of non-steroidal anti-inflammatory drugs (NSAIDs) were associated with cisplatin-induced nephrotoxicity (odds ratios [OR] 6 and 3.56, 95 % confidence intervals [CI] 1.21–29.87 and 1.11–11.39, p = 0.04 and p = 0.04, respectively). Multivariate analysis revealed that cisplatin nephrotoxicity occurred significantly more often in patients with both risk factors (OR 13.64, 95 % CI 1.11–326.83, p = 0.04). Patients with more risk factors for CKD tended to have a greater risk of developing cisplatin-induced AKI.\nConclusions : We should consider avoiding administration of cisplatin to patients with CKD risk factors, particularly cardiac disease and NSAID use. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4268号. 学位記番号: 新大院博(医)甲第746号. 学位授与年月日: 平成29年3月23日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BMC Cancer. 2016; 16: 222 | |||||
書誌情報 | 発行日 2017-03-23 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1186/s12885-016-2271-8 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4268号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第746号 |