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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.

http://hdl.handle.net/10191/47593
http://hdl.handle.net/10191/47593
99359be9-9b7e-40f5-9e0e-6e62bef95384
名前 / ファイル ライセンス アクション
h28nmk740.pdf 本文 (1.0 MB)
h28nmk740_a.pdf 要旨 (196.8 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-11
タイトル
タイトル Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.
タイトル
言語 en
タイトル Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.
言語
言語 eng
キーワード
主題Scheme Other
主題 Angiotensinogen
キーワード
主題Scheme Other
主題 podocyte
キーワード
主題Scheme Other
主題 slit diaphragm
キーワード
主題Scheme Other
主題 nephrin
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル ネフローゼ症候群における糸球体由来アンジオテンシノーゲンの役割
著者 Yamazaki, Mihoko

× Yamazaki, Mihoko

WEKO 50981

Yamazaki, Mihoko

Search repository
著者別名
識別子 50982
識別子Scheme WEKO
姓名 山﨑, 美穂子
抄録
内容記述タイプ Abstract
内容記述 Background and objective: Renin-angiotensin system (RAS) inhibitors reduce glomerular injury and proteinuria, indicating that angiotensin II (Ang II) is involved in glomerular diseases. Although the local RAS is reported to play an essential role in maintaining local tissue functions, the role of the local RAS in regulating glomerular function is not well evaluated. In this study, we analyzed the glomerular expression of RAS components in nephrotic models and the effect of Ang II receptor blockers (ARB) on the expression of angiotensinogen (AGT). \nMethods: The levels of glomerular expression of RAS components were analyzed in two nephrotic models: anti-nephrin antibody-induced nephropathy and PAN nephropathy, a mimic of human minimal change nephrotic syndrome. The effect of the ARB irbesartan on the expression of AGT in the nephrotic model was analyzed. \nResults: Glomerular expression of AGT and the receptors for Ang II was clearly increased in the nephrotic models, while the expression levels of renin, ACE and ACE2 were decreased. ARB treatment suppressed the increase of glomerular expression of AGT in the nephrotic model. \nConclusion: It is conceivable that the promoted local RAS action participated in the glomerular dysfunction, and that ARB treatment ameliorated slit diaphragm injury by inhibiting the positive feedback loop of the activated local Ang II action.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4262号. 学位記番号: 新大院博(医)甲第740号. 学位授与年月日: 平成29年3月23日
内容記述
内容記述タイプ Other
内容記述 Journal of the Renin-Angiotensin-Aldosterone System 17(4),2016
書誌情報 発行日 2017-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1177/1470320316681223
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2017-03-23
学位授与番号
学位授与番号 13101甲第4262号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第740号
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