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Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.
http://hdl.handle.net/10191/47593
http://hdl.handle.net/10191/4759399359be9-9b7e-40f5-9e0e-6e62bef95384
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-09-11 | |||||
タイトル | ||||||
タイトル | Possible role for glomerular-derived angiotensinogen in nephrotic syndrome. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Possible role for glomerular-derived angiotensinogen in nephrotic syndrome. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Angiotensinogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | podocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | slit diaphragm | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nephrin | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | ネフローゼ症候群における糸球体由来アンジオテンシノーゲンの役割 | |||||
著者 |
Yamazaki, Mihoko
× Yamazaki, Mihoko |
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著者別名 | ||||||
識別子 | 50982 | |||||
識別子Scheme | WEKO | |||||
姓名 | 山﨑, 美穂子 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and objective: Renin-angiotensin system (RAS) inhibitors reduce glomerular injury and proteinuria, indicating that angiotensin II (Ang II) is involved in glomerular diseases. Although the local RAS is reported to play an essential role in maintaining local tissue functions, the role of the local RAS in regulating glomerular function is not well evaluated. In this study, we analyzed the glomerular expression of RAS components in nephrotic models and the effect of Ang II receptor blockers (ARB) on the expression of angiotensinogen (AGT). \nMethods: The levels of glomerular expression of RAS components were analyzed in two nephrotic models: anti-nephrin antibody-induced nephropathy and PAN nephropathy, a mimic of human minimal change nephrotic syndrome. The effect of the ARB irbesartan on the expression of AGT in the nephrotic model was analyzed. \nResults: Glomerular expression of AGT and the receptors for Ang II was clearly increased in the nephrotic models, while the expression levels of renin, ACE and ACE2 were decreased. ARB treatment suppressed the increase of glomerular expression of AGT in the nephrotic model. \nConclusion: It is conceivable that the promoted local RAS action participated in the glomerular dysfunction, and that ARB treatment ameliorated slit diaphragm injury by inhibiting the positive feedback loop of the activated local Ang II action. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4262号. 学位記番号: 新大院博(医)甲第740号. 学位授与年月日: 平成29年3月23日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of the Renin-Angiotensin-Aldosterone System 17(4),2016 | |||||
書誌情報 | 発行日 2017-03-23 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1177/1470320316681223 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4262号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第740号 |