{"created":"2021-03-01T06:09:42.553255+00:00","id":5835,"links":{},"metadata":{"_buckets":{"deposit":"d61729f5-af2b-4927-b0db-9639262dbd1d"},"_deposit":{"id":"5835","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5835"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005835","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"肺扁平上皮癌におけるmTORC1シグナル活性低下を介するグルタミン代謝阻害による細胞増殖抑制"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-23","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim: Inhibition of glutaminolysis has been reported as a promising therapeutic strategy to target several solid carcinomas. We aimed to investigate the effects of glutaminolysis on cell proliferation in lung squamous cell carcinoma cell lines and to explore the potential of targeting glutaminolysis as an anticancer strategy. Materials and Methods: Glutamine (Gln) dependence was assessed in six lung squamous cell carcinoma cell lines. Cell proliferation, mammalian target of rapamycin complex 1 (mTORC1) activity and the induction of autophagy were assessed after inhibition of glutaminolysis via Gln depletion or glutaminase (GLS) inhibition. Results: Five of six lung squamous cell carcinoma cell lines exhibited glutamine-dependence. The extent of dependence was correlated with the mRNA levels of GLS1/GLS2. Inhibition of glutaminolysis inhibited cell proliferation by down-regulating of mTORC1 signaling and inducing autophagy in Gln-dependent lung squamous cell carcinoma cell lines. Conclusion: Targeting glutaminolysis may represent a potential therapeutic strategy for the treatment of Gln-dependent lung squamous cell carcinomas.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第4247号. 学位記番号: 新大院博（医）甲第725号. 学位授与年月日: 平成29年3月23日","subitem_description_type":"Other"},{"subitem_description":"Anticancer Research 36(11) 6021-6029(2016)","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第725号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4247号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50955","nameIdentifierScheme":"WEKO"}],"names":[{"name":"叶, 許緑"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.21873/anticanres.11191","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ye, Xu Lu"}],"nameIdentifiers":[{"nameIdentifier":"50954","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28nmk725.pdf","filesize":[{"value":"464.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5835/files/h28nmk725.pdf"},"version_id":"61995744-be1f-4140-9773-2d4128f325a8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28nmk725_a.pdf","filesize":[{"value":"167.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5835/files/h28nmk725_a.pdf"},"version_id":"ecc9c86d-afdc-4269-9bfe-6ed7ef193f7e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lung squamous cell carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"molecular targeted therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"glutaminolysis","subitem_subject_scheme":"Other"},{"subitem_subject":"glutaminase","subitem_subject_scheme":"Other"},{"subitem_subject":"BPTES","subitem_subject_scheme":"Other"},{"subitem_subject":"mTORC1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Inhibition of glutaminolysis inhibits cell growth via down-regulating mTORC1 signaling in lung squamous cell carcinoma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of glutaminolysis inhibits cell growth via down-regulating mTORC1 signaling in lung squamous cell carcinoma."},{"subitem_title":"Inhibition of glutaminolysis inhibits cell growth via down-regulating mTORC1 signaling in lung squamous cell carcinoma.","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-11"},"publish_date":"2018-09-11","publish_status":"0","recid":"5835","relation_version_is_last":true,"title":["Inhibition of glutaminolysis inhibits cell growth via down-regulating mTORC1 signaling in lung squamous cell carcinoma."],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:39:04.126067+00:00"}