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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Possible involvement of mucosal-associated invariant T cells in the progression of inflammatory bowel diseases

http://hdl.handle.net/10191/47576
http://hdl.handle.net/10191/47576
bb08279f-ef90-4c0c-9219-cd8646610c88
名前 / ファイル ライセンス アクション
h28nmk723.pdf 本文 (1.4 MB)
h28nmk723_a.pdf 要旨 (186.0 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-11
タイトル
タイトル Possible involvement of mucosal-associated invariant T cells in the progression of inflammatory bowel diseases
タイトル
言語 en
タイトル Possible involvement of mucosal-associated invariant T cells in the progression of inflammatory bowel diseases
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 炎症性腸疾患の進行におけるMAIT細胞の関与の可能性
著者 Tominaga, Kentaro

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WEKO 50951

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著者別名
識別子 50952
識別子Scheme WEKO
姓名 冨永, 顕太郎
抄録
内容記述タイプ Abstract
内容記述 Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in anti-bacterial immunity. Recent studies have demonstrated that MAIT cells might be implicated in inflammatory bowel diseases (IBDs), but their precise function in IBD remains to be elucidated. We investigated the possible involvement of MAIT cells in the immunopathogenesis of IBDs. Heparinized peripheral blood and biopsy specimens of the colon were collected from 25 patients with ulcerative colitis (UC), 15 patients with Crohn’s disease (CD), and 19 heathy individuals. Lymphocytes were isolated from the blood and colon, and then MAIT cells were analyzed by flow cytometry. The frequency of MAIT cells was significantly lower in the blood of IBD patients compared to healthy donors and significantly higher in the inflamed colons compared to healthy colons (P = 0.001). Among the IBD patients, the frequency of MAIT cells in the blood and colon was correlated with disease activities. In vitro activated MAIT cells from IBD patients secreted significantly more tumor necrosis factor-α and interleukin-17 than those from healthy donors. These findings indicate that MAIT cells are activated in IBD patients, and their accumulation in the inflamed mucosa is correlated with disease activities.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4245号. 学位記番号: 新大院博(医)甲第723号. 学位授与年月日: 平成29年3月23日
内容記述
内容記述タイプ Other
内容記述 Biomedical Research 38(2)111-121 (2017)
書誌情報 発行日 2017-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.2220/biomedres.38.111
権利
権利情報 Copyright © 2017 Biomedical Research Press
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2017-03-23
学位授与番号
学位授与番号 13101甲第4245号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第723号
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