{"created":"2021-03-01T06:09:41.455341+00:00","id":5818,"links":{},"metadata":{"_buckets":{"deposit":"ecbd9bff-32a1-4a7d-a88c-deadaf958ad6"},"_deposit":{"id":"5818","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5818"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005818","sets":["432:433:434","453:455"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Streptococcus mutansに対するMagnololおよびHonokiolの殺菌ならびに抗バイオフィルム効果"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-20","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-20"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dental caries affects people of all ages and is a worldwide health concern. Streptococcus mutans is a major cariogenic bacterium because of its ability to form biofilm and induce an acidic environment. In this study, the antibacterial activities of magnolol and honokiol, the main constituents of the bark of\\nmagnolia plants, toward planktonic cell and biofilm of S. mutans were examined and compared with those of chlorhexidine. The minimal inhibitory concentrations of magnolol, honokiol and chlorhexidine for S. mutans were 10, 10 and 0.25mg/mL, respectively. In addition, each agent showed bactericidal\\nactivity against S.mutans planktonic cells and inhibited biofilmformationin a dose- andtime-dependent manner.Magnolol (50mg/mL) had greater bactericidal activity against S. mutans biofilm than honokiol (50mg/mL) and chlorhexidine (500mg/mL) at 5min after exposure, while all showed scant activity\\nagainst biofilm at 30 s. Furthermore; chlorhexidine (0.5–500mg/mL) exhibited high cellular toxicity for the gingival epithelial cell lineCa9-22 at 1 hr,whereasmagnolol (50mg/mL) and honokiol (50mg/mL) did not. Thus; it was found thatmagnolol has antimicrobial activities against planktonic and biofilm cells of S. mutans. Magnolol may be a candidate for prevention and management of dental caries.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（歯学）. 報告番号: 甲第4224号. 学位記番号: 新大院博（歯）甲第366号. 学位授与年月日: 平成28年9月20日","subitem_description_type":"Other"},{"subitem_description":"Microbiology and Immunology 2016; 60: 10–16","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（歯）甲第366号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4224号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50930","nameIdentifierScheme":"WEKO"}],"names":[{"name":"坂上, 雄樹"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1111/1348-0421.12343","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 The Societies and John Wiley & Sons Australia, Ltd"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakaue, Yuuki"}],"nameIdentifiers":[{"nameIdentifier":"50929","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28ndk366.pdf","filesize":[{"value":"4.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5818/files/h28ndk366.pdf"},"version_id":"199e57c7-8ac8-4a7f-9385-44e418b73e56"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28ndk366_a.pdf","filesize":[{"value":"123.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5818/files/h28ndk366_a.pdf"},"version_id":"bde8a66b-78f1-4e7e-84a7-564587e71ce5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"honokiol","subitem_subject_scheme":"Other"},{"subitem_subject":"magnolia bark","subitem_subject_scheme":"Other"},{"subitem_subject":"magnolol","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus mutans","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans"},{"subitem_title":"Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","434"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-11"},"publish_date":"2018-09-11","publish_status":"0","recid":"5818","relation_version_is_last":true,"title":["Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:39:02.863969+00:00"}