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The aim of the present study was to evaluate whether there is a unique methylation profile of the TNF-a gene promoter in blood cells of individuals with CP and RA. Material and Methods: The study participants consisted of 30 Japanese adults with RA (RA group), 30 race-matched adults with CP only (CP group) and 30 race-matched healthy controls (H group). Genomic DNA isolated from peripheral blood was modified by sodium bisulfite and analyzed, by direct sequencing, to investigate DNA methylation of the TNF-a gene promoter region. The level of TNF-a produced in mononuclear cells stimulated with Porphyromonas gingivalis\\nlipopolysaccharide was determined using ELISA. Results: Twelve cytosine–guanine dinucleotide (CpG) motifs were identified in the TNF-a promoter fragment from  343 to +57 bp. The CP group showed a significantly higher methylation rate and frequency at  72 bp than the H group (p \u003c 0.01). 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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Tumor necrosis factor-alpha gene promoter methylation in Japanese adults with chronic periodontitis and rheumatoid arthritis

http://hdl.handle.net/10191/42134
http://hdl.handle.net/10191/42134
926465a2-9d22-43d8-b3a1-3f310baa2868
名前 / ファイル ライセンス アクション
h27ndk346_b.pdf 要約 (90.6 kB)
h27ndk346_a.pdf 要旨 (223.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-11
タイトル
タイトル Tumor necrosis factor-alpha gene promoter methylation in Japanese adults with chronic periodontitis and rheumatoid arthritis
タイトル
言語 en
タイトル Tumor necrosis factor-alpha gene promoter methylation in Japanese adults with chronic periodontitis and rheumatoid arthritis
言語
言語 eng
キーワード
主題Scheme Other
主題 DNA methylation
キーワード
主題Scheme Other
主題 periodontitis
キーワード
主題Scheme Other
主題 rheumatoid arthritis
キーワード
主題Scheme Other
主題 tumor necrosis factor-alpha
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 日本人慢性歯周炎および関節リウマチ罹患成人におけるTNF-α遺伝子プロモーター領域メチル化の解析
著者 Kojima, Anri

× Kojima, Anri

WEKO 50841

Kojima, Anri

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著者別名
識別子 50842
識別子Scheme WEKO
姓名 小島, 杏里
抄録
内容記述タイプ Abstract
内容記述 "Background and Objective: Over-expression of tumor necrosis factor-alpha (TNF-a) plays a pathological role in chronic periodontitis (CP) and rheumatoid arthritis (RA), which might be regulated by the epigenetic mechanism. The aim of the present study was to evaluate whether there is a unique methylation profile of the TNF-a gene promoter in blood cells of individuals with CP and RA. Material and Methods: The study participants consisted of 30 Japanese adults with RA (RA group), 30 race-matched adults with CP only (CP group) and 30 race-matched healthy controls (H group). Genomic DNA isolated from peripheral blood was modified by sodium bisulfite and analyzed, by direct sequencing, to investigate DNA methylation of the TNF-a gene promoter region. The level of TNF-a produced in mononuclear cells stimulated with Porphyromonas gingivalis\nlipopolysaccharide was determined using ELISA. Results: Twelve cytosine–guanine dinucleotide (CpG) motifs were identified in the TNF-a promoter fragment from 343 to +57 bp. The CP group showed a significantly higher methylation rate and frequency at 72 bp than the H group (p < 0.01). The RA group exhibited significantly higher methylation rates at seven CpG motifs ( 302, 163, 119, 72, 49, 38 and +10 bp), and significantly\nhigher methylation frequencies at six CpG motifs ( 163, 119, 72, 49, 38 and +10 bp), than the H group (p < 0.01 for all comparisons). The levels of TNF-a produced were significantly different between individuals with and without methylation at 163 bp (p = 0.03). Conclusion: These results suggest that the hypermethylated status of CpG motifs in the TNF-a gene promoter in blood cells may be unique to Japanese adults with CP and RA."
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 甲第4148号. 学位記番号: 新大院博(歯)甲第346号. 学位授与年月日: 平成28年3月23日
内容記述
内容記述タイプ Other
内容記述 Journal of Periodontal Research. 2016, 51(3), 350-358.
書誌情報 発行日 2016-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1111/jre.12314
権利
権利情報 【○!C】 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
著者版フラグ
値 none
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2016-03-23
学位授与番号
学位授与番号 13101甲第4148号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第346号
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