{"created":"2021-03-01T06:09:25.189968+00:00","id":5558,"links":{},"metadata":{"_buckets":{"deposit":"22d5f0f0-8d04-4de5-a08d-905651587aa1"},"_deposit":{"id":"5558","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5558"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005558","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"心不全に伴う肝うっ血は貧血に関わらずヘプシジンの不適切分泌の一因となる"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-23","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"29","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepcidin is a key regulator of mammalian iron metabolism and mainly produced by the liver. Hepcidin excess causes iron deficiency and anemia by inhibiting iron absorption from the intestine and iron release from macrophage stores. Anemia is frequently complicated with heart failure. In heart failure patients, the most frequent histologic appearance of liver is congestion. However, it remains unclear whether liver congestion associated with heart failure influences hepcidin production, thereby contributing to anemia and functional iron deficiency. In this study, we investigated this relationship in clinical and basic studies. In clinical studies of consecutive heart failure patients (n =\\n320), anemia was a common comorbidity (41%). In heart failure patients without active infection and ongoing cancer (n = 30), log-serum hepcidin concentration of patients with liver congestion was higher than those without liver congestion (p = 0.0316). Moreover, in heart failure patients with liver congestion (n = 19), the anemia was associated with the higher serum hepcidin concentrations, which is a type of anemia characterized by induction of hepcidin. Subsequently, we produced a rat model of heart failure with liver congestion by injecting monocrotaline that causes pulmonary hypertension. The monocrotaline-treated rats displayed liver congestion with increase of hepcidin expression at 4 weeks after monocrotaline injection, followed by anemia and functional iron deficiency observed at 5 weeks. We conclude that liver congestion induces hepcidin production, which may result in anemia and functional iron deficiency in some patients with heart failure.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第3987号. 学位記番号: 新大院博（医）甲第633号. 学位授与年月日: 平成27年3月23日","subitem_description_type":"Other"},{"subitem_description":"The Tohoku Journal of Experimental Medicine. 2015, 235(1), 69-79.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第633号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第3987号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50490","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大野, 由香子"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1620/tjem.235.69","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (C) 2015 Tohoku University Medical Press"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohno, Yukako"}],"nameIdentifiers":[{"nameIdentifier":"50489","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h26nmk633.pdf","filesize":[{"value":"4.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5558/files/h26nmk633.pdf"},"version_id":"e6a0d134-4749-4515-bcb8-8c4642f083d6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h26nmk633_a.pdf","filesize":[{"value":"179.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5558/files/h26nmk633_a.pdf"},"version_id":"6f6cba26-d5b3-46a2-aa62-8d7bb5569e98"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anemia","subitem_subject_scheme":"Other"},{"subitem_subject":"heart failure","subitem_subject_scheme":"Other"},{"subitem_subject":"hepcidin","subitem_subject_scheme":"Other"},{"subitem_subject":"iron deficiency","subitem_subject_scheme":"Other"},{"subitem_subject":"liver congestion","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia"},{"subitem_title":"Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-03"},"publish_date":"2015-06-03","publish_status":"0","recid":"5558","relation_version_is_last":true,"title":["Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:37:51.283283+00:00"}