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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma

http://hdl.handle.net/10191/32260
http://hdl.handle.net/10191/32260
e0bf2f66-0df0-424f-ad6a-9d58beb07782
名前 / ファイル ライセンス アクション
h26nmk622.pdf 本文 (617.5 kB)
h26nmk622_a.pdf 要旨 (188.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2016-01-04
タイトル
タイトル A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma
タイトル
言語 en
タイトル A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma
言語
言語 eng
キーワード
主題Scheme Other
主題 Chest CT imaging
キーワード
主題Scheme Other
主題 lung adenocarcinoma
キーワード
主題Scheme Other
主題 lung cancer
キーワード
主題Scheme Other
主題 serum CEA levels
キーワード
主題Scheme Other
主題 prognosis
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 術前CT所見と術後血清癌胎児性抗原 (CEA) の値を組み合わせると病理病期 I 期肺腺癌の再発予測能が向上する
著者 Yamazaki, Motohiko

× Yamazaki, Motohiko

WEKO 50467

Yamazaki, Motohiko

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著者別名
識別子 50468
識別子Scheme WEKO
姓名 山崎, 元彦
抄録
内容記述タイプ Abstract
内容記述 Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. Methods: This retrospective study included 250 consecutive patients who underwent complete resection for <__-3-cm pathological stage I (T1–2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P < 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were >__-48% and >__-3.7 ng/mL, respectively. Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第3976号. 学位記番号: 新大院博(医)甲第622号. 学位授与年月日: 平成27年3月23日
内容記述
内容記述タイプ Other
内容記述 European Journal of Radiology. 2015, 84(1), 178-184.
書誌情報 発行日 2015-03-23
出版者
出版者 新潟大学
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2015-03-23
学位授与番号
学位授与番号 13101甲第3976号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第622号
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