{"_buckets": {"deposit": "173b7e6d-8ba3-490a-a991-986851b9b6ac"}, "_deposit": {"id": "5499", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5499"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005499"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f318\u523a\u6fc0\u306b\u3088\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u8caa\u98df\u6a5f\u80fd\u304a\u3088\u3073\u7d30\u80de\u50b7\u5bb3\u6027\u6d3b\u6027\u5897\u5f37\u306b\u95a2\u3059\u308b\u7814\u7a76"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03-24", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "61", "bibliographicPageStart": "1", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2014-03-24"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u7406\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Inoculation of mice with the murine NFSA cell line caused the formation of large tumors with necrotic tumor cores. FACS analysis revealed accumulations of CD11b+ cells in the tumors. Microarray analysis indicated that the NFSA cells expressed a high level of the pro-inflammatory factor interleukin-18 (il-18), which is known to play a critical role in macrophages. However, little is known about the physiological function of IL-18-stimulated macrophages. Here, we provide direct evidence that IL-18 enhances the phagocytosis of RAW264 cells and peritoneal macrophages, accompanied by the increased expression of tumor necrosis factor (tnf-\u03b1), interleukin-6 (il-6) and inducible nitric oxide synthase (Nos2). IL-18-stimulated RAW264 cells showed an enhanced cytotoxicity to endothelial F-2 cells via direct cell-to-cell interaction and the secretion of soluble mediators, including NOS2 derived NO. Taken together, these results demonstrate that tumor-derived IL-18 plays an important role in the phagocytosis of macrophages and that IL-18-stimulated macrophages may damage tumor endothelial cells.", "subitem_description_type": "Abstract"}, {"subitem_description": "\u30de\u30a6\u30b9\u57f9\u990a\u7d30\u80de\u682a\uff0cNFSA\u7d30\u80de\u3092\u30de\u30a6\u30b9\u76ae\u4e0b\u306b\u79fb\u690d\u3059\u308b\u3068\u5de8\u5927\u306a\u816b\u760d\u3092\u5f62\u6210\u3057\uff0c\u305d\u306e\u4e2d\u5fc3\u90e8\u306f\u58ca\u6b7b\u3092\u8d77\u3053\u3059\u3002FACS (\u81ea\u52d5\u7d30\u80de\u89e3\u6790\u6355\u96c6\u88c5\u7f6e) 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[{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Studies on Enhancement of Phagocytosis and Cytotoxicity in Macrophages by IL-18-Stimulation.", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Studies on Enhancement of Phagocytosis and Cytotoxicity in Macrophages by IL-18-Stimulation."}, {"subitem_title": "Studies on Enhancement of Phagocytosis and Cytotoxicity in Macrophages by IL-18-Stimulation.", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "468/563/564"], "permalink_uri": "http://hdl.handle.net/10191/27260", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-05-19"}, "publish_date": "2014-05-19", "publish_status": "0", "recid": "5499", "relation": {}, "relation_version_is_last": true, "title": ["Studies on Enhancement of Phagocytosis and Cytotoxicity in Macrophages by IL-18-Stimulation."], "weko_shared_id": 2}