@misc{oai:niigata-u.repo.nii.ac.jp:00005471,
 author = {Miyota, Shun},
 month = {Mar},
 note = {Background:Local recurrenceremains a challenging clinical issue for the treatment of oral squamous cell carcinoma (SCC).Weanalyzed retrospectively how effective the frozen section technique (FS)was against recurrences of oral SCC. Methods: We screened 343 surgical samples from 236 patients who hadoral SCC, carcinoma in-situ (CIS), or epithelial dysplasia, and we followed up their clinical outcomes for at least 5 years. The patients were classified into relapseand relapse-freegroupsaccording to the patients’ local recurrence histories, and theirhistopathological states of surgical margins were compared between primary and recurrent lesions. Result: Among the 236 patients,191 (80.9%, 191 samples; 115 males vs. 76 females) were classified into the relapse-free group, and 45 (19.1%, 152 samples, 27 females vs. 18 males)intothe relapse group.FS was more frequentlyperformedin the relapse-free group (128/191, 67.0%) than in the relapse group (83/152, 54.6%). Histopathologically,moderate dysplasia or CIS (borderline malignancies, BMs), and SCCwere recognized in 55 samples (43.0%) of the relapse-free group and in 57(68.7%) of the relapse group.For thosesurgicalmarginswith BMs, additional incisionswereperformed in 38 (69.1%) of the 55 relapse-free cases, which reduced to 20from the 38 BM margins (40% reduction), and in 39 (68.4%) of the 57 relapse cases (7.6% reduction). Conclusion:These results indicate thatthe intraoperative assessment of surgicalmarginsby FS is essential in preventing recurrencesof oral mucosal malignancies., 学位の種類: 博士（歯学）. 報告番号: 甲第3888号. 学位記番号: 新大院博（歯）甲第307号. 学位授与年月日: 平成26年3月24日, 新大院博（歯）甲第307号},
 title = {Intraoperative assessment of surgical margins of oral squamous cell carcinoma using frozen sections : a practical clinicopathological management for recurrences},
 year = {2014}
}