@misc{oai:niigata-u.repo.nii.ac.jp:00005421, author = {Hasegawa, Naoya}, month = {Mar}, note = {Background: Individuals with autistic spectrum disorder (ASD) demonstrate an impaired ability to infer the mental states of others from their gaze. Thus, investigating the relationship between ASD and eye gaze processing is crucial for understanding the neural basis of social impairments seen in individuals with ASD. In addition, characteristics of ASD are observed in more comprehensive visual perception tasks. These visual characteristics of ASD have been well-explained in terms of the atypical relationship between high and low-level gaze processing in ASD. Method: We studied neural activity during gaze processing in individuals with ASD using magnetoencephalography, with a focus on the relationship between high and low-level gaze processing both temporally and spatially. Minimum current estimate analysis was applied to perform source analysis of magnetic responses to gaze stimuli. Results: The source analysis showed that later activity in the primary visual area (V1) was affected by gaze direction only in the ASD group. Conversely, the right posterior superior temporal sulcus, which is a brain region that processes gaze as a social signal, in the typically developed group showed a tendency toward greater activation during direct compared with averted gaze processing. Conclusion: These results suggest that later activity in V1 relating to gaze processing is altered or possibly enhanced in high-functioning individuals with ASD, which may underpin the social cognitive impairments in these individuals., 学位の種類: 博士(医学). 報告番号: 甲第3859号. 学位記番号: 新大院博(医)甲第599号. 学位授与年月日: 平成26年3月24日, Neuropsychobiology. 2013, 68(3), 181-188, 新大院博(医)甲第599号}, title = {Altered Activity of the Primary Visual Area during Gaze Processing in Individuals with High-Functioning Autistic Spectrum Disorder : A Magnetoencephalography Study}, year = {2014} }