{"created":"2021-03-01T06:09:14.915186+00:00","id":5393,"links":{},"metadata":{"_buckets":{"deposit":"418f4e71-007a-40b3-a972-61e8c2fcdd98"},"_deposit":{"id":"5393","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5393"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005393","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Expression of Pentraxin 3 in neutrophilic granules"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-24","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-24"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pentraxinは免疫反応に重要な役割を果たす5量体の蛋白で、pentraxin 3 (PTX3)やC-reactive protein (CRP)はpentraxin superfamily に属する。pentraxin 3 (PTX3) は炎症性刺激に曝されるとマクロファージ、好中球、血管内皮細胞など様々な細胞から産生され、好中球ではPTX3は細胞質内の顆粒に局在する。好中球の顆粒は1次顆粒、2次顆粒、3次顆粒の3種に分けられ、 PTX3 は2次顆粒（特殊顆粒）に存在すると考えられてきた。しかし、他の顆粒における局在については不明であった。本研究では成熟好中球と好中球へ分化誘導した前骨髄球性細胞株HL-60細胞を検討し、すべての顆粒にPTX3が存在することを確認した。IL-8の刺激によって好中球はneutrophil extracellular traps (NETs) と呼ばれる不規則な網状形態を示したが、3種の顆粒はこのNETsの表面に接着し、PTX3はこれら顆粒と共局在した。以上の成績からPTX3は好中球の細胞質内および細胞外の顆粒構成抗菌性蛋白と共存し、生体防御上、重要な役割を果たしていることが推測された。","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第3831号. 学位記番号: 新大院博（医）甲第571号. 学位授与年月日: 平成26年3月24日","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第571号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第3831号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50198","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Razvina, Olga"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ラズビナ, オリガ"}],"nameIdentifiers":[{"nameIdentifier":"50197","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h25nmk571.pdf","filesize":[{"value":"890.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5393/files/h25nmk571.pdf"},"version_id":"0b8d3b8f-f027-4fab-8966-dc6e98e1f179"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h25nmk571_a.pdf","filesize":[{"value":"223.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5393/files/h25nmk571_a.pdf"},"version_id":"ce1f6d71-714f-43ec-9cff-c6c0a13fc099"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pentraxin 3","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球顆粒","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil extracellular traps (NETs)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"好中球顆粒におけるPentraxin 3 の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"好中球顆粒におけるPentraxin 3 の発現"},{"subitem_title":"好中球顆粒におけるPentraxin 3 の発現","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-22"},"publish_date":"2014-05-22","publish_status":"0","recid":"5393","relation_version_is_last":true,"title":["好中球顆粒におけるPentraxin 3 の発現"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:37:50.875073+00:00"}