{"created":"2021-03-01T06:08:12.353980+00:00","id":4407,"links":{},"metadata":{"_buckets":{"deposit":"6a73b5e4-9774-4f99-b9ec-0f0bbd9d6b14"},"_deposit":{"id":"4407","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4407"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00004407","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clinical Evaluation of Plasma Concentrations of Protein induced by Vitamin K Absence or Antagonist-II (PIVIKA-II ), and its Altered Glycosylation in Patients with Hepatocellular Carcinoma (HCC)."}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-04-23","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"38","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1992-04-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The plasma concentrations of PIVIKA-II in samples from 155 patients with HCC and 298 with other liver diseases were determined. The serum concentrations and fucosylation index of alpha-fetoprotein (AFP), sialyl stage-specific embryonic antigen-1 (SLX), CA-50, and Dupan-2 were also determined in 60 patients with HCC, 70 with nonneoplastic liver diseases and 25 with carcinoma metastatic to the liver. In 16 HCC patients with positive 'reactions of both PIVKA-II and AFP longitudinal series of their plasma concentrations were measured in evaluating the effect of the treatment to HCC. Next, the reactivity of PIVKA-II , AFP, prothrombin, transferrin and alpha-1-antitrypsin with concanavalin A and Lens culinaris agglutinin was studied in 11 patients with HCC by crossed jinmunoaffino-electrophoresis and affinity colomn chromatography. The results are as follow: 1. The plasma concentrations of PIVKA-II in patients with HCC were higher than those with other liver diseases with statistical significance, and the sensitivity, specificity and total accuracy of the present analysis were 54, 98 and 85%, respectively. 2. The determinations of serum concentrations and fucosylation index of AFP and SLX were also useful for diagnosing HCC, and 88% of HCC was able to be dingnosed by the measurement of these markers together with PIVKA-II serologically. 3. Simultaneous determinations of PIVKA-II and AFP were recommended in the follow-up of patients with HCC since 5 HCC patients with the dissociation of the concentrations of PIVKA-II and AFP were observed. 4. Concanavalin A-nonreactive fraction of PLVKA-II was detected in serum from patient with HCC, suggesting an altered glycosylation of PIVKA-II.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 乙第1301号. 学位記番号: 新大博（医）乙第1209号. 学位授与年月日: 平成4年4月23日","subitem_description_type":"Other"},{"subitem_description":"新潟医学会雑誌. 1992, 106(11), 1055-1068.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大博（医）乙第1209号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101B1301"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"48393","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Oguro, Makoto"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小黒, 仁"}],"nameIdentifiers":[{"nameIdentifier":"48392","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"000000251560.pdf","filesize":[{"value":"4.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/4407/files/000000251560.pdf"},"version_id":"e588d409-91d6-4500-87c4-8f81a30fbc66"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatocellular carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"protein induced by vitamin K absence or antagonist-II(PIVKA-II)","subitem_subject_scheme":"Other"},{"subitem_subject":"altered glycosylation","subitem_subject_scheme":"Other"},{"subitem_subject":"肝細胞癌","subitem_subject_scheme":"Other"},{"subitem_subject":"異常プロトロンビン(PIVKA-II)","subitem_subject_scheme":"Other"},{"subitem_subject":"糖鎖変異","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"肝細胞癌診断におけるPIVKA-IIならびに各種腫瘍マーカー測定の臨床的意義とその糖鎖変異に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌診断におけるPIVKA-IIならびに各種腫瘍マーカー測定の臨床的意義とその糖鎖変異に関する研究"},{"subitem_title":"肝細胞癌診断におけるPIVKA-IIならびに各種腫瘍マーカー測定の臨床的意義とその糖鎖変異に関する研究","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-10"},"publish_date":"2013-10-10","publish_status":"0","recid":"4407","relation_version_is_last":true,"title":["肝細胞癌診断におけるPIVKA-IIならびに各種腫瘍マーカー測定の臨床的意義とその糖鎖変異に関する研究"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:37:17.776889+00:00"}