{"created":"2021-03-01T06:08:12.291220+00:00","id":4406,"links":{},"metadata":{"_buckets":{"deposit":"25cfcb3b-54f5-4e77-b7d1-96d603509b01"},"_deposit":{"id":"4406","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4406"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00004406","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Methylene Blue on the Relaxation and Increses in CyclicGMP Concentrations of Vascular Smooth Muscle Produced by NO-formingVasodilators and Atriopeptin"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"32","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1992-03-31"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaN0_2, sodium nitroprusside (SNP) and atriopeptin(ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KG1), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60 min-MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第855号. 学位記番号: 新大院博（医）甲第651号. 学位授与年月日: 平成4年3月31日","subitem_description_type":"Other"},{"subitem_description":"新潟医学会雑誌. 1992, 106(7), 631-641.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第651号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101A855"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"48391","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sasage, Hiroki"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"捧, 博輝"}],"nameIdentifiers":[{"nameIdentifier":"48390","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"000000251430.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/4406/files/000000251430.pdf"},"version_id":"c7bbabf7-d675-4b13-9b7f-bd41a58a030d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vascular smooth muscle","subitem_subject_scheme":"Other"},{"subitem_subject":"NO-forming vasodilators","subitem_subject_scheme":"Other"},{"subitem_subject":"atriopeptin","subitem_subject_scheme":"Other"},{"subitem_subject":"methylene blue","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclic GMP","subitem_subject_scheme":"Other"},{"subitem_subject":"血管平滑筋","subitem_subject_scheme":"Other"},{"subitem_subject":"心房性ナトリウム利尿ホルモン","subitem_subject_scheme":"Other"},{"subitem_subject":"メチレンブルー","subitem_subject_scheme":"Other"},{"subitem_subject":"サイクリックGMP","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について"},{"subitem_title":"NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-10"},"publish_date":"2013-10-10","publish_status":"0","recid":"4406","relation_version_is_last":true,"title":["NO-forming vasodilators と atriopeptin による血管平滑筋の弛緩とcyclic GMP 増加に対する methylene blue の効果について"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:37:17.811068+00:00"}